Found 7 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50103946
(3-(4-((5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl...)Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(F)cc(F)c2)cc1)C(O)=O Show InChI InChI=1S/C21H20F2N2O5/c1-12(2)29-18(21(26)27)7-13-3-5-17(6-4-13)28-11-19-24-20(30-25-19)14-8-15(22)10-16(23)9-14/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Agonist activity against human Peroxisome proliferator activated receptor gamma receptor in CV-1 cell was determined |
Bioorg Med Chem Lett 11: 2385-8 (2001)
BindingDB Entry DOI: 10.7270/Q2CJ8CSF |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human)) | BDBM50103946
(3-(4-((5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl...)Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(F)cc(F)c2)cc1)C(O)=O Show InChI InChI=1S/C21H20F2N2O5/c1-12(2)29-18(21(26)27)7-13-3-5-17(6-4-13)28-11-19-24-20(30-25-19)14-8-15(22)10-16(23)9-14/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Agonist activity against human PPAR delta receptor in CV-1 cell was determined |
Bioorg Med Chem Lett 11: 2385-8 (2001)
BindingDB Entry DOI: 10.7270/Q2CJ8CSF |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human)) | BDBM50103946
(3-(4-((5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl...)Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(F)cc(F)c2)cc1)C(O)=O Show InChI InChI=1S/C21H20F2N2O5/c1-12(2)29-18(21(26)27)7-13-3-5-17(6-4-13)28-11-19-24-20(30-25-19)14-8-15(22)10-16(23)9-14/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Agonist activity against human Peroxisome proliferator activated receptor alpha receptor in CV-1 cell was determined |
Bioorg Med Chem Lett 11: 2385-8 (2001)
BindingDB Entry DOI: 10.7270/Q2CJ8CSF |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human)) | BDBM50103946
(3-(4-((5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl...)Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(F)cc(F)c2)cc1)C(O)=O Show InChI InChI=1S/C21H20F2N2O5/c1-12(2)29-18(21(26)27)7-13-3-5-17(6-4-13)28-11-19-24-20(30-25-19)14-8-15(22)10-16(23)9-14/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | n/a | n/a | 2.50E+7 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at PPARalpha (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-004-0110-y BindingDB Entry DOI: 10.7270/Q2DJ5JH3 |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50103946
(3-(4-((5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl...)Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(F)cc(F)c2)cc1)C(O)=O Show InChI InChI=1S/C21H20F2N2O5/c1-12(2)29-18(21(26)27)7-13-3-5-17(6-4-13)28-11-19-24-20(30-25-19)14-8-15(22)10-16(23)9-14/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research
Curated by ChEMBL
| Assay Description Agonist activity at human PPARgamma expressed in african green monkey CV1 cells cotransfected with Gal4 assessed as reporter activty by transient tra... |
Eur J Med Chem 43: 2784-91 (2008)
Article DOI: 10.1016/j.ejmech.2008.01.017 BindingDB Entry DOI: 10.7270/Q2W095QK |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human)) | BDBM50103946
(3-(4-((5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl...)Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(F)cc(F)c2)cc1)C(O)=O Show InChI InChI=1S/C21H20F2N2O5/c1-12(2)29-18(21(26)27)7-13-3-5-17(6-4-13)28-11-19-24-20(30-25-19)14-8-15(22)10-16(23)9-14/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research
Curated by ChEMBL
| Assay Description Agonist activity at human PPARdelta expressed in african green monkey CV1 cells cotransfected with Gal4 assessed as reporter activty by transient tra... |
Eur J Med Chem 43: 2784-91 (2008)
Article DOI: 10.1016/j.ejmech.2008.01.017 BindingDB Entry DOI: 10.7270/Q2W095QK |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human)) | BDBM50103946
(3-(4-((5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl...)Show SMILES CC(C)OC(Cc1ccc(OCc2noc(n2)-c2cc(F)cc(F)c2)cc1)C(O)=O Show InChI InChI=1S/C21H20F2N2O5/c1-12(2)29-18(21(26)27)7-13-3-5-17(6-4-13)28-11-19-24-20(30-25-19)14-8-15(22)10-16(23)9-14/h3-6,8-10,12,18H,7,11H2,1-2H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research
Curated by ChEMBL
| Assay Description Agonist activity at human PPARalpha expressed in african green monkey CV1 cells cotransfected with Gal4 assessed as reporter activty by transient tra... |
Eur J Med Chem 43: 2784-91 (2008)
Article DOI: 10.1016/j.ejmech.2008.01.017 BindingDB Entry DOI: 10.7270/Q2W095QK |
More data for this Ligand-Target Pair | |