Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50019686
(2-Isopropyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-...)Show SMILES CC(C)c1ccc2nc3ccc(cn3c(=O)c2c1)C(=O)NCCCCc1cncnc1 Show InChI InChI=1S/C24H25N5O2/c1-16(2)18-6-8-21-20(11-18)24(31)29-14-19(7-9-22(29)28-21)23(30)27-10-4-3-5-17-12-25-15-26-13-17/h6-9,11-16H,3-5,10H2,1-2H3,(H,27,30) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human platelet thromboxane synthase (TXA2) was determined in human platelets |
J Med Chem 30: 185-93 (1987)
BindingDB Entry DOI: 10.7270/Q2222VBH |
More data for this
Ligand-Target Pair | |
Platelet-activating factor receptor
(Homo sapiens (Human)) | BDBM50019686
(2-Isopropyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-...)Show SMILES CC(C)c1ccc2nc3ccc(cn3c(=O)c2c1)C(=O)NCCCCc1cncnc1 Show InChI InChI=1S/C24H25N5O2/c1-16(2)18-6-8-21-20(11-18)24(31)29-14-19(7-9-22(29)28-21)23(30)27-10-4-3-5-17-12-25-15-26-13-17/h6-9,11-16H,3-5,10H2,1-2H3,(H,27,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]-PAF as radioligand |
J Med Chem 31: 466-72 (1988)
BindingDB Entry DOI: 10.7270/Q2KK99S6 |
More data for this
Ligand-Target Pair | |