Found 1243 hits Enz. Inhib. hit(s) with Target = 'Thromboxane-A synthase' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Thromboxane-A synthase
(MOUSE) | BDBM50008780
(7-{3-[3-Hydroxy-4-(4-iodo-phenoxy)-but-1-enyl]-7-o...)Show SMILES O[C@@H](COc1ccc(I)cc1)\C=C\[C@H]1C2CC[C@H](O2)[C@@H]1C\C=C/CCCC(O)=O Show InChI InChI=1S/C23H29IO5/c24-16-7-10-18(11-8-16)28-15-17(25)9-12-20-19(21-13-14-22(20)29-21)5-3-1-2-4-6-23(26)27/h1,3,7-12,17,19-22,25H,2,4-6,13-15H2,(H,26,27)/b3-1-,12-9+/t17-,19-,20-,21+,22?/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.560 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by PDSP Ki Database
| |
Br J Pharmacol 122: 217-24 (1997)
Article DOI: 10.1038/sj.bjp.0701367 BindingDB Entry DOI: 10.7270/Q26M35CT |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(MOUSE) | BDBM50008805
(7-(3-Benzenesulfonylamino-bicyclo[2.2.1]hept-2-yl)...)Show SMILES OC(=O)CCC\C=C/C[C@H]1[C@@H]2CCC(C2)C1NS(=O)(=O)c1ccccc1 Show InChI InChI=1S/C20H27NO4S/c22-19(23)11-7-2-1-6-10-18-15-12-13-16(14-15)20(18)21-26(24,25)17-8-4-3-5-9-17/h1,3-6,8-9,15-16,18,20-21H,2,7,10-14H2,(H,22,23)/b6-1-/t15-,16?,18+,20?/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by PDSP Ki Database
| |
Br J Pharmacol 122: 217-24 (1997)
Article DOI: 10.1038/sj.bjp.0701367 BindingDB Entry DOI: 10.7270/Q26M35CT |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50188619
(1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-b...)Show SMILES Cc1ccc(Nc2ccc(cc2S(=O)(=O)NC(=O)NC(C)(C)C)[N+]([O-])=O)cc1 Show InChI InChI=1S/C18H22N4O5S/c1-12-5-7-13(8-6-12)19-15-10-9-14(22(24)25)11-16(15)28(26,27)21-17(23)20-18(2,3)4/h5-11,19H,1-4H3,(H2,20,21,23) | KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li&eagrove;ge
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 313: 293-301 (2005)
Article DOI: 10.1124/jpet.104.079301 BindingDB Entry DOI: 10.7270/Q2NV9GVJ |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50167939
(3,4-DNH | 5-Hydroxy Tryptamine | BM 613 | Benzen |...) | KEGG
UniProtKB/SwissProt
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| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Li&eagrove;ge
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 313: 293-301 (2005)
Article DOI: 10.1124/jpet.104.079301 BindingDB Entry DOI: 10.7270/Q2NV9GVJ |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(MOUSE) | BDBM50283049
((Z)-7-[(1R,2R,3S,5S)-5-(Biphenyl-4-ylmethoxy)-3-hy...)Show SMILES O[C@H]1C[C@H](OCc2ccc(cc2)-c2ccccc2)[C@H](CC\C=C/CCC(O)=O)[C@H]1N1CCCCC1 Show InChI InChI=1S/C30H39NO4/c32-27-21-28(35-22-23-15-17-25(18-16-23)24-11-5-3-6-12-24)26(13-7-1-2-8-14-29(33)34)30(27)31-19-9-4-10-20-31/h1-3,5-6,11-12,15-18,26-28,30,32H,4,7-10,13-14,19-22H2,(H,33,34)/b2-1-/t26-,27-,28-,30+/m0/s1 | Reactome pathway KEGG
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by PDSP Ki Database
| |
Br J Pharmacol 122: 217-24 (1997)
Article DOI: 10.1038/sj.bjp.0701367 BindingDB Entry DOI: 10.7270/Q26M35CT |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(MOUSE) | BDBM50008781
(7-(3-(2-ethyl-N-phenylhydrazinecarboxamide)-7-oxa-...)Show SMILES OC(=O)CCC\C=C/C[C@H]1[C@@H]2CCC(O2)[C@H]1CNNC(=O)Nc1ccccc1 Show InChI InChI=1S/C21H29N3O4/c25-20(26)11-7-2-1-6-10-16-17(19-13-12-18(16)28-19)14-22-24-21(27)23-15-8-4-3-5-9-15/h1,3-6,8-9,16-19,22H,2,7,10-14H2,(H,25,26)(H2,23,24,27)/b6-1-/t16-,17+,18+,19?/m1/s1 | Reactome pathway KEGG
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by PDSP Ki Database
| |
Br J Pharmacol 122: 217-24 (1997)
Article DOI: 10.1038/sj.bjp.0701367 BindingDB Entry DOI: 10.7270/Q26M35CT |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(MOUSE) | BDBM81948
(CAS_89617-02-7 | ONO 11,113 | ONO-11113 | STA2)Show SMILES CCCCC[C@H](O)\C=C\C1C[C@H]2C[C@H](S2)[C@@H]1C\C=C/CCCC(O)=O |r| Show InChI InChI=1S/C21H34O3S/c1-2-3-6-9-17(22)13-12-16-14-18-15-20(25-18)19(16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16?,17-,18-,19+,20-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| PC cid PC sid UniChem
| Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by PDSP Ki Database
| |
Br J Pharmacol 122: 217-24 (1997)
Article DOI: 10.1038/sj.bjp.0701367 BindingDB Entry DOI: 10.7270/Q26M35CT |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(MOUSE) | BDBM50018531
((Z)-7-[(S)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-2-oxa-...)Show SMILES CCCCC[C@H](O)\C=C\C1[C@H]2C[C@H](CO2)[C@@H]1C\C=C/CCCC(O)=O Show InChI InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18+,19?,20-/m1/s1 | Reactome pathway KEGG
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| 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by PDSP Ki Database
| |
Br J Pharmacol 122: 217-24 (1997)
Article DOI: 10.1038/sj.bjp.0701367 BindingDB Entry DOI: 10.7270/Q26M35CT |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(MOUSE) | BDBM85177
(CAS_80558-61-8 | M&B-28767 | NSC_119139)Show SMILES OC(COc1ccccc1)C=CC1CCC(=O)C1CCCCCCC(O)=O |w:11.12| Show InChI InChI=1S/C22H30O5/c23-18(16-27-19-8-4-3-5-9-19)14-12-17-13-15-21(24)20(17)10-6-1-2-7-11-22(25)26/h3-5,8-9,12,14,17-18,20,23H,1-2,6-7,10-11,13,15-16H2,(H,25,26) | Reactome pathway KEGG
UniProtKB/SwissProt
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| PC cid PC sid UniChem
| Article PubMed
| 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by PDSP Ki Database
| |
Br J Pharmacol 122: 217-24 (1997)
Article DOI: 10.1038/sj.bjp.0701367 BindingDB Entry DOI: 10.7270/Q26M35CT |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM86692
(K117)Show SMILES CC(C)C(=O)N(C1CC(C)N(C(=O)c2ccccc2)c2ccccc12)c1ccccc1 Show InChI InChI=1S/C27H28N2O2/c1-19(2)26(30)29(22-14-8-5-9-15-22)25-18-20(3)28(24-17-11-10-16-23(24)25)27(31)21-12-6-4-7-13-21/h4-17,19-20,25H,18H2,1-3H3 | KEGG
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 314: 244-51 (2005)
Article DOI: 10.1124/jpet.104.081539 BindingDB Entry DOI: 10.7270/Q2RN36FF |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM86693
(K376)Show SMILES CCC(=O)N1C(C)CC(N(C(C)=O)c2ccccc2)c2ccccc12 Show InChI InChI=1S/C21H24N2O2/c1-4-21(25)22-15(2)14-20(18-12-8-9-13-19(18)22)23(16(3)24)17-10-6-5-7-11-17/h5-13,15,20H,4,14H2,1-3H3 | KEGG
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 314: 244-51 (2005)
Article DOI: 10.1124/jpet.104.081539 BindingDB Entry DOI: 10.7270/Q2RN36FF |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(BOVINE) | BDBM86757
(CAS_0 | NSC_11603174 | [11C]MMP)Show InChI InChI=1S/C19H27N5O3/c1-21-18(25)15-20-24(19(21)26)10-6-5-9-22-11-13-23(14-12-22)16-7-3-4-8-17(16)27-2/h3-4,7-8,15H,5-6,9-14H2,1-2H3 | UniProtKB/SwissProt
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| PC cid PC sid UniChem
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Similars
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Columbia University
Curated by PDSP Ki Database
| |
Eur J Nucl Med Mol Imaging 34: 1050-60 (2007)
Article DOI: 10.1007/s00259-006-0324-y BindingDB Entry DOI: 10.7270/Q2D7990W |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM86691
(K604)Show SMILES CC1CC(N(C(=O)C2CC2)c2ccccc2)c2ccccc2N1C(=O)c1ccccc1 Show InChI InChI=1S/C27H26N2O2/c1-19-18-25(29(27(31)21-16-17-21)22-12-6-3-7-13-22)23-14-8-9-15-24(23)28(19)26(30)20-10-4-2-5-11-20/h2-15,19,21,25H,16-18H2,1H3 | KEGG
UniProtKB/SwissProt
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| PC cid PC sid UniChem
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 314: 244-51 (2005)
Article DOI: 10.1124/jpet.104.081539 BindingDB Entry DOI: 10.7270/Q2RN36FF |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50010960
((E)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-...)Show InChI InChI=1S/C18H19NO2/c20-18(21)12-6-2-5-11-17(15-8-3-1-4-9-15)16-10-7-13-19-14-16/h1,3-4,7-11,13-14H,2,5-6,12H2,(H,20,21)/b17-11+ | KEGG
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| n/a | n/a | 0.890 | n/a | n/a | n/a | n/a | n/a | n/a |
Nikken Chemicals Co., Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibition of TXB2 production by incubating prostaglandin H2 with human platelet microsomes. |
Bioorg Med Chem Lett 12: 341-4 (2002)
BindingDB Entry DOI: 10.7270/Q2ST7P56 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50026486
((Z)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-...)Show InChI InChI=1S/C18H19NO2/c20-18(21)12-6-2-5-11-17(15-8-3-1-4-9-15)16-10-7-13-19-14-16/h1,3-4,7-11,13-14H,2,5-6,12H2,(H,20,21)/b17-11- | KEGG
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| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Nikken Chemicals Co., Ltd.
Curated by ChEMBL
| Assay Description Thromboxane A2 synthase inhibitory activity was measured from inhibition of thromboxane B2 production in human platelet microsomes |
Bioorg Med Chem Lett 12: 1383-6 (2002)
BindingDB Entry DOI: 10.7270/Q2MG7NT9 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50026486
((Z)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-...)Show InChI InChI=1S/C18H19NO2/c20-18(21)12-6-2-5-11-17(15-8-3-1-4-9-15)16-10-7-13-19-14-16/h1,3-4,7-11,13-14H,2,5-6,12H2,(H,20,21)/b17-11- | KEGG
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| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Nikken Chemicals Co., Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibition of thromboxane synthase (TXA2) in human platelet microsomes [reduced formation of TXB2 from prostaglandin H2(PGH2)] |
Bioorg Med Chem Lett 12: 771-4 (2002)
BindingDB Entry DOI: 10.7270/Q23X85ZH |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50109140
(5-[1-Phenyl-1-pyridin-3-yl-meth-(Z)-ylideneaminoox...)Show InChI InChI=1S/C19H22N2O3/c1-2-23-18(22)12-6-7-14-24-21-19(16-9-4-3-5-10-16)17-11-8-13-20-15-17/h3-5,8-11,13,15H,2,6-7,12,14H2,1H3/b21-19- | KEGG
UniProtKB/SwissProt
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Nikken Chemicals Co., Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibition of TXB2 production by incubating prostaglandin H2 with human platelet microsomes. |
Bioorg Med Chem Lett 12: 341-4 (2002)
BindingDB Entry DOI: 10.7270/Q2ST7P56 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003792
(8-(4-Fluoro-benzenesulfonylamino)-4-(3-pyridin-3-y...)Show SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(F)cc1)CCCc1cccnc1 Show InChI InChI=1S/C22H29FN2O4S/c23-20-10-12-21(13-11-20)30(28,29)25-16-2-1-5-18(9-14-22(26)27)6-3-7-19-8-4-15-24-17-19/h4,8,10-13,15,17-18,25H,1-3,5-7,9,14,16H2,(H,26,27) | KEGG
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description In vitro inhibition of Thromboxane A2 synthase |
J Med Chem 35: 4373-83 (1992)
BindingDB Entry DOI: 10.7270/Q2F47N3W |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003784
(8-(4-Chloro-benzenesulfonylamino)-4-[3-(4-methyl-p...)Show SMILES Cc1ccncc1CCCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCC(O)=O Show InChI InChI=1S/C23H31ClN2O4S/c1-18-14-16-25-17-20(18)7-4-6-19(8-13-23(27)28)5-2-3-15-26-31(29,30)22-11-9-21(24)10-12-22/h9-12,14,16-17,19,26H,2-8,13,15H2,1H3,(H,27,28) | KEGG
UniProtKB/SwissProt
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Patents
Similars
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description In vitro inhibition of Thromboxane A2 synthase |
J Med Chem 35: 4373-83 (1992)
BindingDB Entry DOI: 10.7270/Q2F47N3W |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003780
(4-(3-Pyridin-3-yl-propyl)-8-(toluene-4-sulfonylami...)Show SMILES Cc1ccc(cc1)S(=O)(=O)NCCCCC(CCCc1cccnc1)CCC(O)=O Show InChI InChI=1S/C23H32N2O4S/c1-19-10-13-22(14-11-19)30(28,29)25-17-3-2-6-20(12-15-23(26)27)7-4-8-21-9-5-16-24-18-21/h5,9-11,13-14,16,18,20,25H,2-4,6-8,12,15,17H2,1H3,(H,26,27) | KEGG
UniProtKB/SwissProt
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Similars
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description In vitro inhibition of Thromboxane A2 synthase |
J Med Chem 35: 4373-83 (1992)
BindingDB Entry DOI: 10.7270/Q2F47N3W |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50043839
((E)-6-[2-(4-Fluoro-benzenesulfonylamino)-indan-5-y...)Show SMILES OC(=O)CCC\C=C(\c1cccnc1)c1ccc2CC(Cc2c1)NS(=O)(=O)c1ccc(F)cc1 Show InChI InChI=1S/C26H25FN2O4S/c27-22-9-11-24(12-10-22)34(32,33)29-23-15-18-7-8-19(14-21(18)16-23)25(5-1-2-6-26(30)31)20-4-3-13-28-17-20/h3-5,7-14,17,23,29H,1-2,6,15-16H2,(H,30,31)/b25-5+ | KEGG
UniProtKB/SwissProt
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Dr. Karl Thomae GmbH
Curated by ChEMBL
| Assay Description Inhibition test of thromboxane A2 synthetase in human gel-filtered platelets. |
J Med Chem 37: 26-39 (1994)
BindingDB Entry DOI: 10.7270/Q2SB44T4 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50110458
(5-(Phenyl-pyridin-3-yl-methyleneaminooxy)-pentanoi...)Show InChI InChI=1S/C19H22N2O3/c1-2-23-18(22)12-6-7-14-24-21-19(16-9-4-3-5-10-16)17-11-8-13-20-15-17/h3-5,8-11,13,15H,2,6-7,12,14H2,1H3/b21-19+ | KEGG
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Similars
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Nikken Chemicals Co., Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibition of thromboxane synthase (TXA2) in human platelet microsomes [reduced formation of TXB2 from prostaglandin H2(PGH2)] |
Bioorg Med Chem Lett 12: 771-4 (2002)
BindingDB Entry DOI: 10.7270/Q23X85ZH |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50109134
(5-[1-Pyridin-3-yl-1-{3-[(3-pyridin-3-yl-1H-pyrrolo...)Show SMILES CCOC(=O)CCCCO\N=C(/c1cccnc1)c1cccc(NC(=O)c2ccn3C(SCc23)c2cccnc2)c1 Show InChI InChI=1S/C31H31N5O4S/c1-2-39-28(37)12-3-4-17-40-35-29(23-9-6-14-32-19-23)22-8-5-11-25(18-22)34-30(38)26-13-16-36-27(26)21-41-31(36)24-10-7-15-33-20-24/h5-11,13-16,18-20,31H,2-4,12,17,21H2,1H3,(H,34,38)/b35-29- | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Nikken Chemicals Co., Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibition of TXB2 production by incubating prostaglandin H2 with human platelet microsomes. |
Bioorg Med Chem Lett 12: 341-4 (2002)
BindingDB Entry DOI: 10.7270/Q2ST7P56 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003803
(8-(Naphthalene-2-sulfonylamino)-4-(3-pyridin-3-yl-...)Show SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc2ccccc2c1)CCCc1cccnc1 Show InChI InChI=1S/C26H32N2O4S/c29-26(30)16-13-21(8-5-9-22-10-6-17-27-20-22)7-3-4-18-28-33(31,32)25-15-14-23-11-1-2-12-24(23)19-25/h1-2,6,10-12,14-15,17,19-21,28H,3-5,7-9,13,16,18H2,(H,29,30) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description In vitro inhibition of Thromboxane A2 synthase |
J Med Chem 35: 4373-83 (1992)
BindingDB Entry DOI: 10.7270/Q2F47N3W |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50109124
(5-[1-(3-{[4-(2-Methyl-imidazo[4,5-c]pyridin-1-ylme...)Show SMILES Cc1nc2cnccc2n1Cc1ccc(cc1)S(=O)(=O)NCc1cccc(c1)C(=N/OCCCCC(O)=O)\c1cccnc1 Show InChI InChI=1S/C32H32N6O5S/c1-23-36-29-21-34-16-14-30(29)38(23)22-24-10-12-28(13-11-24)44(41,42)35-19-25-6-4-7-26(18-25)32(27-8-5-15-33-20-27)37-43-17-3-2-9-31(39)40/h4-8,10-16,18,20-21,35H,2-3,9,17,19,22H2,1H3,(H,39,40)/b37-32+ | KEGG
UniProtKB/SwissProt
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Similars
| PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Nikken Chemicals Co., Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibition of TXB2 production by incubating prostaglandin H2 with human platelet microsomes. |
Bioorg Med Chem Lett 12: 341-4 (2002)
BindingDB Entry DOI: 10.7270/Q2ST7P56 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Rattus norvegicus) | BDBM50024903
(6-Chloro-3-(4-imidazol-1-yl-butyl)-1H-quinazoline-...)Show InChI InChI=1S/C15H15ClN4O2/c16-11-3-4-13-12(9-11)14(21)20(15(22)18-13)7-2-1-6-19-8-5-17-10-19/h3-5,8-10H,1-2,6-7H2,(H,18,22) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical Research Division of American Cyanamid Company
Curated by ChEMBL
| Assay Description Tested for inhibition of thromboxane synthetase from spontaneously hypertensive rats |
J Med Chem 30: 2277-83 (1988)
BindingDB Entry DOI: 10.7270/Q23T9HT6 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003781
(CHEMBL341686 | [5-(4-Chloro-benzenesulfonylamino)-...)Show SMILES OC(=O)CSC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1 Show InChI InChI=1S/C21H27ClN2O4S2/c22-18-9-11-20(12-10-18)30(27,28)24-14-2-1-7-19(29-16-21(25)26)8-3-5-17-6-4-13-23-15-17/h4,6,9-13,15,19,24H,1-3,5,7-8,14,16H2,(H,25,26) | KEGG
UniProtKB/SwissProt
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Patents
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description In vitro inhibition of Thromboxane A2 synthase |
J Med Chem 35: 4373-83 (1992)
BindingDB Entry DOI: 10.7270/Q2F47N3W |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003801
(4-(3-Pyridin-3-yl-propyl)-8-(4-trifluoromethyl-ben...)Show SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(cc1)C(F)(F)F)CCCc1cccnc1 Show InChI InChI=1S/C23H29F3N2O4S/c24-23(25,26)20-10-12-21(13-11-20)33(31,32)28-16-2-1-5-18(9-14-22(29)30)6-3-7-19-8-4-15-27-17-19/h4,8,10-13,15,17-18,28H,1-3,5-7,9,14,16H2,(H,29,30) | KEGG
UniProtKB/SwissProt
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Patents
Similars
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description In vitro inhibition of Thromboxane A2 synthase |
J Med Chem 35: 4373-83 (1992)
BindingDB Entry DOI: 10.7270/Q2F47N3W |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003776
(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)Show SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1 Show InChI InChI=1S/C22H29ClN2O4S/c23-20-10-12-21(13-11-20)30(28,29)25-16-2-1-5-18(9-14-22(26)27)6-3-7-19-8-4-15-24-17-19/h4,8,10-13,15,17-18,25H,1-3,5-7,9,14,16H2,(H,26,27) | KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description In vitro inhibition of thromboxane synthasase in microsomal platelet preparation |
J Med Chem 36: 205-10 (1993)
BindingDB Entry DOI: 10.7270/Q2XS5TFK |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50043826
(6-{4-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-phe...)Show SMILES OC(=O)CCCCC(c1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1)c1cccnc1 Show InChI InChI=1S/C25H27ClN2O4S/c26-22-11-13-23(14-12-22)33(31,32)28-17-15-19-7-9-20(10-8-19)24(5-1-2-6-25(29)30)21-4-3-16-27-18-21/h3-4,7-14,16,18,24,28H,1-2,5-6,15,17H2,(H,29,30) | KEGG
UniProtKB/SwissProt
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Similars
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Dr. Karl Thomae GmbH
Curated by ChEMBL
| Assay Description Inhibition test of thromboxane A2 synthetase in human gel-filtered platelets. |
J Med Chem 37: 26-39 (1994)
BindingDB Entry DOI: 10.7270/Q2SB44T4 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Rattus norvegicus) | BDBM50037039
(2-Amino-5,7-dimethyl-4-pyridin-3-ylmethyl-benzothi...)Show InChI InChI=1S/C15H15N3OS/c1-8-11(6-10-4-3-5-17-7-10)12-14(9(2)13(8)19)20-15(16)18-12/h3-5,7,19H,6H2,1-2H3,(H2,16,18) | Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibitory activity against the production of thromboxane B2 (TXB2) in glycogen-induced peritoneal cells of rat |
J Med Chem 37: 3062-70 (1994)
BindingDB Entry DOI: 10.7270/Q2WM1F2J |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50038591
(6-(5-Chloro-1-methyl-2-pyridin-3-yl-1H-indol-3-yl)...)Show InChI InChI=1S/C20H21ClN2O2/c1-23-18-10-9-15(21)12-17(18)16(7-3-2-4-8-19(24)25)20(23)14-6-5-11-22-13-14/h5-6,9-13H,2-4,7-8H2,1H3,(H,24,25) | KEGG
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description Tested for 50% inhibition of thromboxane synthase (TxS) in human platelets (in vitro) |
J Med Chem 37: 1823-32 (1994)
BindingDB Entry DOI: 10.7270/Q280537C |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003776
(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)Show SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1 Show InChI InChI=1S/C22H29ClN2O4S/c23-20-10-12-21(13-11-20)30(28,29)25-16-2-1-5-18(9-14-22(26)27)6-3-7-19-8-4-15-24-17-19/h4,8,10-13,15,17-18,25H,1-3,5-7,9,14,16H2,(H,26,27) | KEGG
UniProtKB/SwissProt
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Similars
| Article
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of thromboxane synthase |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7 BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003776
(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)Show SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1 Show InChI InChI=1S/C22H29ClN2O4S/c23-20-10-12-21(13-11-20)30(28,29)25-16-2-1-5-18(9-14-22(26)27)6-3-7-19-8-4-15-24-17-19/h4,8,10-13,15,17-18,25H,1-3,5-7,9,14,16H2,(H,26,27) | KEGG
UniProtKB/SwissProt
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Patents
Similars
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description The compound was tested in vitro for its inhibitory activity against thromboxane synthase A2 (TXA2) |
J Med Chem 35: 4366-72 (1992)
BindingDB Entry DOI: 10.7270/Q2JW8CVB |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Rattus norvegicus) | BDBM50024948
(6-Chloro-3-(7-imidazol-1-yl-heptyl)-1H-quinazoline...)Show SMILES Clc1ccc2[nH]c(=O)n(CCCCCCCn3ccnc3)c(=O)c2c1 Show InChI InChI=1S/C18H21ClN4O2/c19-14-6-7-16-15(12-14)17(24)23(18(25)21-16)10-5-3-1-2-4-9-22-11-8-20-13-22/h6-8,11-13H,1-5,9-10H2,(H,21,25) | Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical Research Division of American Cyanamid Company
Curated by ChEMBL
| Assay Description Tested for inhibition of thromboxane synthetase from spontaneously hypertensive rats |
J Med Chem 30: 2277-83 (1988)
BindingDB Entry DOI: 10.7270/Q23T9HT6 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003776
(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)Show SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1 Show InChI InChI=1S/C22H29ClN2O4S/c23-20-10-12-21(13-11-20)30(28,29)25-16-2-1-5-18(9-14-22(26)27)6-3-7-19-8-4-15-24-17-19/h4,8,10-13,15,17-18,25H,1-3,5-7,9,14,16H2,(H,26,27) | KEGG
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Patents
Similars
| Article
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of the compound against thromboxane synthase |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9 BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50020743
(CHEMBL53346 | Sodium; (+)-7-(3-benzenesulfonylamin...)Show SMILES [O-]C(=O)CCC\C=C/C[C@H]1[C@@H]2CCC(C2)[C@@H]1NS(=O)(=O)c1ccccc1 Show InChI InChI=1S/C20H27NO4S/c22-19(23)11-7-2-1-6-10-18-15-12-13-16(14-15)20(18)21-26(24,25)17-8-4-3-5-9-17/h1,3-6,8-9,15-16,18,20-21H,2,7,10-14H2,(H,22,23)/p-1/b6-1-/t15-,16?,18+,20+/m1/s1 | KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shionogi & Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of thromboxane A2 synthetase from human platelets by 1 uM of the compound |
J Med Chem 31: 1847-54 (1988)
BindingDB Entry DOI: 10.7270/Q2G44P95 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50072779
((E)-7-{4-[4-(2-Phenoxy-ethylcarbamoyl)-oxazol-2-yl...)Show SMILES OC(=O)CCCC\C=C(/c1ccc(cc1)-c1nc(co1)C(=O)NCCOc1ccccc1)c1cccnc1 Show InChI InChI=1S/C30H29N3O5/c34-28(35)12-6-2-5-11-26(24-8-7-17-31-20-24)22-13-15-23(16-14-22)30-33-27(21-38-30)29(36)32-18-19-37-25-9-3-1-4-10-25/h1,3-4,7-11,13-17,20-21H,2,5-6,12,18-19H2,(H,32,36)(H,34,35)/b26-11+ | KEGG
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Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description In vitro for inhibitory activity against thromboxane synthase |
J Med Chem 41: 5362-74 (1999)
Article DOI: 10.1021/jm980173n BindingDB Entry DOI: 10.7270/Q2V123Z8 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003797
(8-(4-Chloro-benzenesulfonylamino)-4-[2-(pyridin-3-...)Show SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCOc1cccnc1 Show InChI InChI=1S/C21H27ClN2O5S/c22-18-7-9-20(10-8-18)30(27,28)24-14-2-1-4-17(6-11-21(25)26)12-15-29-19-5-3-13-23-16-19/h3,5,7-10,13,16-17,24H,1-2,4,6,11-12,14-15H2,(H,25,26) | KEGG
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Similars
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| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description In vitro inhibition of thromboxane synthasase in microsomal platelet preparation |
J Med Chem 36: 205-10 (1993)
BindingDB Entry DOI: 10.7270/Q2XS5TFK |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50072778
((E)-7-(4-{4-[3-(4-Methoxy-phenyl)-propylcarbamoyl]...)Show SMILES COc1ccc(CCCNC(=O)c2coc(n2)-c2ccc(cc2)C(=C/CCCCC(O)=O)\c2cccnc2)cc1 Show InChI InChI=1S/C32H33N3O5/c1-39-27-17-11-23(12-18-27)7-5-20-34-31(38)29-22-40-32(35-29)25-15-13-24(14-16-25)28(26-8-6-19-33-21-26)9-3-2-4-10-30(36)37/h6,8-9,11-19,21-22H,2-5,7,10,20H2,1H3,(H,34,38)(H,36,37)/b28-9+ | KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description In vitro for inhibitory activity against thromboxane synthase |
J Med Chem 41: 5362-74 (1999)
Article DOI: 10.1021/jm980173n BindingDB Entry DOI: 10.7270/Q2V123Z8 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50010960
((E)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-...)Show InChI InChI=1S/C18H19NO2/c20-18(21)12-6-2-5-11-17(15-8-3-1-4-9-15)16-10-7-13-19-14-16/h1,3-4,7-11,13-14H,2,5-6,12H2,(H,20,21)/b17-11+ | KEGG
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| PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description Activity against TXA2 synthase in bovine platelet microsome |
J Med Chem 36: 1613-8 (1993)
BindingDB Entry DOI: 10.7270/Q2639NTJ |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM7962
(4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...)Show InChI InChI=1S/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16) | KEGG
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of thromboxane TXA2 synthetase from human platelets |
J Med Chem 29: 1643-50 (1986)
BindingDB Entry DOI: 10.7270/Q2C8289W |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM7962
(4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...)Show InChI InChI=1S/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16) | KEGG
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of TXA2 synthetase from human platelets |
J Med Chem 29: 342-6 (1986)
BindingDB Entry DOI: 10.7270/Q2W66JSZ |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50008790
(5-[Pyridin-4-yl-(3-trifluoromethyl-phenyl)-methyle...)Show SMILES OC(=O)CCCCO\N=C(/c1ccncc1)c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C18H17F3N2O3/c19-18(20,21)15-5-3-4-14(12-15)17(13-7-9-22-10-8-13)23-26-11-2-1-6-16(24)25/h3-5,7-10,12H,1-2,6,11H2,(H,24,25)/b23-17+ | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description Compound was evaluated in vitro for the inhibition of Thromboxane synthase using [14C]-arachidonic acid as radioligand |
J Med Chem 34: 1790-7 (1991)
BindingDB Entry DOI: 10.7270/Q2BR8R47 |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003797
(8-(4-Chloro-benzenesulfonylamino)-4-[2-(pyridin-3-...)Show SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCOc1cccnc1 Show InChI InChI=1S/C21H27ClN2O5S/c22-18-7-9-20(10-8-18)30(27,28)24-14-2-1-4-17(6-11-21(25)26)12-15-29-19-5-3-13-23-16-19/h3,5,7-10,13,16-17,24H,1-2,4,6,11-12,14-15H2,(H,25,26) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation
Curated by ChEMBL
| Assay Description In vitro inhibition of Thromboxane A2 synthase |
J Med Chem 35: 4373-83 (1992)
BindingDB Entry DOI: 10.7270/Q2F47N3W |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50075618
(6-{3-[2-cyano-1-cyclopentylamino-(E)-1-iminomethyl...)Show SMILES OC(=O)CCCC=C(c1cccnc1)c1cccc(NC(NC2CCCC2)=NC#N)c1 |w:27.29,6.5| Show InChI InChI=1S/C24H27N5O2/c25-17-27-24(28-20-9-1-2-10-20)29-21-11-5-7-18(15-21)22(12-3-4-13-23(30)31)19-8-6-14-26-16-19/h5-8,11-12,14-16,20H,1-4,9-10,13H2,(H,30,31)(H2,27,28,29) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma KG
Curated by ChEMBL
| Assay Description In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets. |
J Med Chem 42: 1235-49 (1999)
Article DOI: 10.1021/jm9707941 BindingDB Entry DOI: 10.7270/Q2H41QMS |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50075644
((E)-6-[3-({[(E)-Benzenesulfonylimino]-tert-butylam...)Show SMILES CC(C)(C)N=C(Nc1cccc(c1)C(=CCCCC(O)=O)c1cccnc1)NS(=O)(=O)c1ccccc1 |w:4.3,14.15| Show InChI InChI=1S/C28H32N4O4S/c1-28(2,3)31-27(32-37(35,36)24-14-5-4-6-15-24)30-23-13-9-11-21(19-23)25(16-7-8-17-26(33)34)22-12-10-18-29-20-22/h4-6,9-16,18-20H,7-8,17H2,1-3H3,(H,33,34)(H2,30,31,32) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma KG
Curated by ChEMBL
| Assay Description In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets. |
J Med Chem 42: 1235-49 (1999)
Article DOI: 10.1021/jm9707941 BindingDB Entry DOI: 10.7270/Q2H41QMS |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50075645
(6-{3-[2-cyano-1-cyclohexylamino-(E)-1-iminomethyla...)Show SMILES OC(=O)CCCC=C(c1cccnc1)c1cccc(NC(NC2CCCCC2)=NC#N)c1 |w:28.30,6.5| Show InChI InChI=1S/C25H29N5O2/c26-18-28-25(29-21-10-2-1-3-11-21)30-22-12-6-8-19(16-22)23(13-4-5-14-24(31)32)20-9-7-15-27-17-20/h6-9,12-13,15-17,21H,1-5,10-11,14H2,(H,31,32)(H2,28,29,30) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma KG
Curated by ChEMBL
| Assay Description In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets. |
J Med Chem 42: 1235-49 (1999)
Article DOI: 10.1021/jm9707941 BindingDB Entry DOI: 10.7270/Q2H41QMS |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50075637
(6-{3-[2-cyano-1-isopentylamino-(E)-1-iminomethylam...)Show SMILES CC(C)CCNC(Nc1cccc(c1)C(=CCCCC(O)=O)c1cccnc1)=NC#N |w:28.30,15.16| Show InChI InChI=1S/C24H29N5O2/c1-18(2)12-14-27-24(28-17-25)29-21-9-5-7-19(15-21)22(10-3-4-11-23(30)31)20-8-6-13-26-16-20/h5-10,13,15-16,18H,3-4,11-12,14H2,1-2H3,(H,30,31)(H2,27,28,29) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma KG
Curated by ChEMBL
| Assay Description In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets. |
J Med Chem 42: 1235-49 (1999)
Article DOI: 10.1021/jm9707941 BindingDB Entry DOI: 10.7270/Q2H41QMS |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50075630
(6-{3-[1-(1-adamantylamino)-2-cyano-(E)-1-iminometh...)Show SMILES OC(=O)CCCC=C(c1cccnc1)c1cccc(NC(NC23CC4CC(CC(C4)C2)C3)=NC#N)c1 |w:32.36,6.5,TLB:29:28:31:24.23.25,29:24:31:28.30.27,25:26:30:24.23.29,THB:25:24:30:26.31.27| Show InChI InChI=1S/C29H33N5O2/c30-19-32-28(34-29-15-20-11-21(16-29)13-22(12-20)17-29)33-25-7-3-5-23(14-25)26(8-1-2-9-27(35)36)24-6-4-10-31-18-24/h3-8,10,14,18,20-22H,1-2,9,11-13,15-17H2,(H,35,36)(H2,32,33,34) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma KG
Curated by ChEMBL
| Assay Description In vitro activity on thromboxane A2 synthase inhibition in gel filtered human platelets. |
J Med Chem 42: 1235-49 (1999)
Article DOI: 10.1021/jm9707941 BindingDB Entry DOI: 10.7270/Q2H41QMS |
More data for this Ligand-Target Pair | |