| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane-A synthase |
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| Ligand | BDBM50038591 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_209414 (CHEMBL816621) |
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| IC50 | 2±n/a nM |
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| Citation |  Ksander, GM; Erion, M; Yuan, AM; Diefenbacher, CG; el-Chehabi, L; Cote, D; Levens, N Dual angiotensin converting enzyme/thromboxane synthase inhibitors. J Med Chem37:1823-32 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane-A synthase |
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| Name: | Thromboxane-A synthase |
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| Synonyms: | CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 60524.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24557 |
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| Residue: | 533 |
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| Sequence: | MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
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| BDBM50038591 |
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| n/a |
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| Name | BDBM50038591 |
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| Synonyms: | 6-(5-Chloro-1-methyl-2-pyridin-3-yl-1H-indol-3-yl)-hexanoic acid | CHEMBL301550 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21ClN2O2 |
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| Mol. Mass. | 356.846 |
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| SMILES | Cn1c(c(CCCCCC(O)=O)c2cc(Cl)ccc12)-c1cccnc1 |
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| Structure | 
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