Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thyroid hormone receptor alpha (Homo sapiens (Human)) | BDBM18860 ((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha (unknown origin) expressed in sf9 cells by scintillation proximity assay | Proc Natl Acad Sci U S A 104: 15490-5 (2007) Article DOI: 10.1073/pnas.0702759104 BindingDB Entry DOI: 10.7270/Q2JW8DPH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM18869 (2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50115668 (3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Thyroid hormone receptor alpha (Homo sapiens (Human)) | BDBM18860 ((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM18869 (2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]T3 from recombinant thyroid hormone receptor beta (unknown origin) expressed in sf9 cells by scintillation proximity assay | Proc Natl Acad Sci U S A 104: 15490-5 (2007) Article DOI: 10.1073/pnas.0702759104 BindingDB Entry DOI: 10.7270/Q2JW8DPH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50036402 (CHEMBL46882 | N-[3,5-dimethyl-4-(4'-hydroxy-3'-iso...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor alpha (Homo sapiens (Human)) | BDBM50036402 (CHEMBL46882 | N-[3,5-dimethyl-4-(4'-hydroxy-3'-iso...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM18860 ((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]T3 from recombinant thyroid hormone receptor beta (unknown origin) expressed in sf9 cells by scintillation proximity assay | Proc Natl Acad Sci U S A 104: 15490-5 (2007) Article DOI: 10.1073/pnas.0702759104 BindingDB Entry DOI: 10.7270/Q2JW8DPH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM18860 ((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | 0.680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50274809 (3,5-Diiodo-4-(4'-hydroxy-3'-isopropylphenoxy)benzy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 0.840 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50274812 (CHEMBL457528 | [3,5-Diiodo-4-(4'-hydroxy-3'-isopro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 0.970 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor alpha (Homo sapiens (Human)) | BDBM50115668 (3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phen...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 1.09 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50274846 (CHEMBL511862 | [3,5-Dibromo-4-(4'-hydroxy-3'-isopr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 1.51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor alpha (Homo sapiens (Human)) | BDBM50274809 (3,5-Diiodo-4-(4'-hydroxy-3'-isopropylphenoxy)benzy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 1.84 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 3 (Homo sapiens (Human)) | BDBM50096172 (1-Bromo-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant human E-type adenylate deaminase | J Med Chem 44: 613-8 (2001) BindingDB Entry DOI: 10.7270/Q2BZ659R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50242403 ((3,5-dimethyl-4-(4-hydroxy-3-isopropylbenzyl)pheno...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]T3 from recombinant thyroid hormone receptor beta (unknown origin) expressed in sf9 cells by scintillation proximity assay | Proc Natl Acad Sci U S A 104: 15490-5 (2007) Article DOI: 10.1073/pnas.0702759104 BindingDB Entry DOI: 10.7270/Q2JW8DPH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50275295 (2-[3,5-Dibromo-4-(4'-hydroxy-3'-isopropylphenoxy)p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50274811 (CHEMBL457527 | [3,5-Dibromo-4-(4'-hydroxy-3'-isopr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 2.51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50242403 ((3,5-dimethyl-4-(4-hydroxy-3-isopropylbenzyl)pheno...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor alpha (Homo sapiens (Human)) | BDBM50274812 (CHEMBL457528 | [3,5-Diiodo-4-(4'-hydroxy-3'-isopro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 3.74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor IX (Homo sapiens (Human)) | BDBM352478 (US9809545, 5b) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba... | US Patent US9809545 (2017) BindingDB Entry DOI: 10.7270/Q24Q7X4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor IX (Homo sapiens (Human)) | BDBM352476 (US9809545, 4Cl) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba... | US Patent US9809545 (2017) BindingDB Entry DOI: 10.7270/Q24Q7X4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor IX (Homo sapiens (Human)) | BDBM352469 (US9809545, 4Aa) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba... | US Patent US9809545 (2017) BindingDB Entry DOI: 10.7270/Q24Q7X4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor IX (Homo sapiens (Human)) | BDBM352466 (US9809545, 3Bd) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba... | US Patent US9809545 (2017) BindingDB Entry DOI: 10.7270/Q24Q7X4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor IX (Homo sapiens (Human)) | BDBM352464 (US9809545, 3g) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba... | US Patent US9809545 (2017) BindingDB Entry DOI: 10.7270/Q24Q7X4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor IX (Homo sapiens (Human)) | BDBM352460 (US9809545, 1Ef) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba... | US Patent US9809545 (2017) BindingDB Entry DOI: 10.7270/Q24Q7X4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor IX (Homo sapiens (Human)) | BDBM352458 (US9809545, 1Bc) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba... | US Patent US9809545 (2017) BindingDB Entry DOI: 10.7270/Q24Q7X4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Mus musculus) | BDBM50039549 (3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity against Purine nucleoside Phosphorylase from calf spleen | J Med Chem 36: 3771-83 (1994) BindingDB Entry DOI: 10.7270/Q23J3DKS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor IX (Homo sapiens (Human)) | BDBM352461 (US9809545, 1Ff) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba... | US Patent US9809545 (2017) BindingDB Entry DOI: 10.7270/Q24Q7X4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor IX (Homo sapiens (Human)) | BDBM352459 (US9809545, 1Ea) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba... | US Patent US9809545 (2017) BindingDB Entry DOI: 10.7270/Q24Q7X4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50275257 (CHEMBL448595 | [3,5-Dimethyl-4-(3'-sec-butyl-4'-hy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 6.64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Thyroid hormone receptor alpha (Homo sapiens (Human)) | BDBM18869 (2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 7.18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha (unknown origin) expressed in sf9 cells by scintillation proximity assay | Proc Natl Acad Sci U S A 104: 15490-5 (2007) Article DOI: 10.1073/pnas.0702759104 BindingDB Entry DOI: 10.7270/Q2JW8DPH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Thyroid hormone receptor alpha (Homo sapiens (Human)) | BDBM18869 (2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 7.79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50033666 (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4 | J Med Chem 36: 3771-83 (1994) BindingDB Entry DOI: 10.7270/Q23J3DKS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50033666 (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity against hydrophobic pocket of Purine nucleoside Phosphorylase | J Med Chem 36: 3771-83 (1994) BindingDB Entry DOI: 10.7270/Q23J3DKS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50033666 (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4 | J Med Chem 36: 3771-83 (1994) BindingDB Entry DOI: 10.7270/Q23J3DKS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 3 (Homo sapiens (Human)) | BDBM50096166 (1-Benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant human E-type adenylate deaminase | J Med Chem 44: 613-8 (2001) BindingDB Entry DOI: 10.7270/Q2BZ659R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50275291 (CHEMBL485758 | [4-(4'-Hydroxy-3'-isopropylbenzyl)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50275228 (CHEMBL485928 | [3,5-Dimethyl-4-(3'-ethyl-4'-hydrox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 9.72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor alpha (Homo sapiens (Human)) | BDBM50274846 (CHEMBL511862 | [3,5-Dibromo-4-(4'-hydroxy-3'-isopr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 10.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Bos taurus (bovine)) | BDBM50046234 (2-Amino-7-benzyl-3,4a,5,7a-tetrahydro-pyrrolo[3,2-...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of purine nucleoside phosphorylase against the enzyme from calf spleen in 1 mM phosphate | J Med Chem 36: 55-69 (1993) BindingDB Entry DOI: 10.7270/Q2B27TCX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 3 (Homo sapiens (Human)) | BDBM50096165 (4-[2-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant human E-type adenylate deaminase | J Med Chem 44: 613-8 (2001) BindingDB Entry DOI: 10.7270/Q2BZ659R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Bos taurus (bovine)) | BDBM50046239 (2-Amino-9-thiophen-3-ylmethyl-1,9-dihydro-purin-6-...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 1 mM phosphate | J Med Chem 36: 55-69 (1993) BindingDB Entry DOI: 10.7270/Q2B27TCX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50275294 (CHEMBL519721 | [3,5-Dibromo-4-(4'-hydroxy-3'-isopr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 15.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor alpha (Homo sapiens (Human)) | BDBM50274810 (3,5-Diiodo-4-(4'-hydroxy-3'-iodophenoxy)benzylphos...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor IX (Homo sapiens (Human)) | BDBM352473 (US9809545, 4Bn) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba... | US Patent US9809545 (2017) BindingDB Entry DOI: 10.7270/Q24Q7X4Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor alpha (Homo sapiens (Human)) | BDBM50274811 (CHEMBL457527 | [3,5-Dibromo-4-(4'-hydroxy-3'-isopr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 18.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
AMP deaminase 3 (Homo sapiens (Human)) | BDBM50096169 (4-[2-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant human E-type adenylate deaminase | J Med Chem 44: 613-8 (2001) BindingDB Entry DOI: 10.7270/Q2BZ659R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50274813 (CHEMBL457529 | [3,5-Dimethyl-4-(4'-hydroxy-3'-isop...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 25.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50274810 (3,5-Diiodo-4-(4'-hydroxy-3'-iodophenoxy)benzylphos...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc. Curated by ChEMBL | Assay Description Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | J Med Chem 51: 7075-93 (2009) Article DOI: 10.1021/jm800824d BindingDB Entry DOI: 10.7270/Q21V5DT5 | |||||||||||
More data for this Ligand-Target Pair |
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