Found 6 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM444529
(US10662186, Compound 49 | US10988476, Compound I-4...)Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCO)ncc1F Show InChI InChI=1S/C26H28F2N8O2/c1-14(2)36-15(3)31-24-18(27)10-17(11-21(24)36)23-19(28)12-30-25(34-23)33-22-5-4-16-13-35(8-6-20(16)32-22)26(38)29-7-9-37/h4-5,10-12,14,37H,6-9,13H2,1-3H3,(H,29,38)(H,30,32,33,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| KEGG
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.36 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10662186 (2020)
BindingDB Entry DOI: 10.7270/Q2GX4FKS |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM444529
(US10662186, Compound 49 | US10988476, Compound I-4...)Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCO)ncc1F Show InChI InChI=1S/C26H28F2N8O2/c1-14(2)36-15(3)31-24-18(27)10-17(11-21(24)36)23-19(28)12-30-25(34-23)33-22-5-4-16-13-35(8-6-20(16)32-22)26(38)29-7-9-37/h4-5,10-12,14,37H,6-9,13H2,1-3H3,(H,29,38)(H,30,32,33,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.36 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10988476 (2021)
BindingDB Entry DOI: 10.7270/Q2PR8047 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM444529
(US10662186, Compound 49 | US10988476, Compound I-4...)Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCO)ncc1F Show InChI InChI=1S/C26H28F2N8O2/c1-14(2)36-15(3)31-24-18(27)10-17(11-21(24)36)23-19(28)12-30-25(34-23)33-22-5-4-16-13-35(8-6-20(16)32-22)26(38)29-7-9-37/h4-5,10-12,14,37H,6-9,13H2,1-3H3,(H,29,38)(H,30,32,33,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.17 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10988476 (2021)
BindingDB Entry DOI: 10.7270/Q2PR8047 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM444529
(US10662186, Compound 49 | US10988476, Compound I-4...)Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCO)ncc1F Show InChI InChI=1S/C26H28F2N8O2/c1-14(2)36-15(3)31-24-18(27)10-17(11-21(24)36)23-19(28)12-30-25(34-23)33-22-5-4-16-13-35(8-6-20(16)32-22)26(38)29-7-9-37/h4-5,10-12,14,37H,6-9,13H2,1-3H3,(H,29,38)(H,30,32,33,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.17 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10662186 (2020)
BindingDB Entry DOI: 10.7270/Q2GX4FKS |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM444529
(US10662186, Compound 49 | US10988476, Compound I-4...)Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCO)ncc1F Show InChI InChI=1S/C26H28F2N8O2/c1-14(2)36-15(3)31-24-18(27)10-17(11-21(24)36)23-19(28)12-30-25(34-23)33-22-5-4-16-13-35(8-6-20(16)32-22)26(38)29-7-9-37/h4-5,10-12,14,37H,6-9,13H2,1-3H3,(H,29,38)(H,30,32,33,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 28.2 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10988476 (2021)
BindingDB Entry DOI: 10.7270/Q2PR8047 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM444529
(US10662186, Compound 49 | US10988476, Compound I-4...)Show SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCO)ncc1F Show InChI InChI=1S/C26H28F2N8O2/c1-14(2)36-15(3)31-24-18(27)10-17(11-21(24)36)23-19(28)12-30-25(34-23)33-22-5-4-16-13-35(8-6-20(16)32-22)26(38)29-7-9-37/h4-5,10-12,14,37H,6-9,13H2,1-3H3,(H,29,38)(H,30,32,33,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 28.2 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
US Patent
| Assay Description
1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100... |
US Patent US10662186 (2020)
BindingDB Entry DOI: 10.7270/Q2GX4FKS |
More data for this
Ligand-Target Pair | |