| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
|---|
| Ligand | BDBM444529 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | LANCE Ultra ULight Assay |
|---|
| IC50 | 28.2±n/a nM |
|---|
| Citation |  Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y Substituted pyrimidines as cyclin-dependent kinase inhibitors US Patent US10662186 Publication Date 5/26/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 2 |
|---|
| Name: | Cyclin-dependent kinase 2 |
|---|
| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33938.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P24941 |
|---|
| Residue: | 298 |
|---|
| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
|
|
|
|---|
| BDBM444529 |
|---|
| n/a |
|---|
| Name | BDBM444529 |
|---|
| Synonyms: | US10662186, Compound 49 | US10988476, Compound I-49 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H28F2N8O2 |
|---|
| Mol. Mass. | 522.5497 |
|---|
| SMILES | CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCO)ncc1F |
|---|
| Structure | 
|
|---|
Search and Browse
