Found 8 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340876
(3-(dibenzo[b,d]thiophen-4-yl)-1-isopropyl-1H- pyra...)Show SMILES CC(C)n1nc(-c2cccc3c4ccccc4sc23)c2c(N)ncnc12 Show InChI InChI=1S/C20H17N5S/c1-11(2)25-20-16(19(21)22-10-23-20)17(24-25)14-8-5-7-13-12-6-3-4-9-15(12)26-18(13)14/h3-11H,1-2H3,(H2,21,22,23) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM340876
(3-(dibenzo[b,d]thiophen-4-yl)-1-isopropyl-1H- pyra...)Show SMILES CC(C)n1nc(-c2cccc3c4ccccc4sc23)c2c(N)ncnc12 Show InChI InChI=1S/C20H17N5S/c1-11(2)25-20-16(19(21)22-10-23-20)17(24-25)14-8-5-7-13-12-6-3-4-9-15(12)26-18(13)14/h3-11H,1-2H3,(H2,21,22,23) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340876
(3-(dibenzo[b,d]thiophen-4-yl)-1-isopropyl-1H- pyra...)Show SMILES CC(C)n1nc(-c2cccc3c4ccccc4sc23)c2c(N)ncnc12 Show InChI InChI=1S/C20H17N5S/c1-11(2)25-20-16(19(21)22-10-23-20)17(24-25)14-8-5-7-13-12-6-3-4-9-15(12)26-18(13)14/h3-11H,1-2H3,(H2,21,22,23) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II)) | BDBM340876
(3-(dibenzo[b,d]thiophen-4-yl)-1-isopropyl-1H- pyra...)Show SMILES CC(C)n1nc(-c2cccc3c4ccccc4sc23)c2c(N)ncnc12 Show InChI InChI=1S/C20H17N5S/c1-11(2)25-20-16(19(21)22-10-23-20)17(24-25)14-8-5-7-13-12-6-3-4-9-15(12)26-18(13)14/h3-11H,1-2H3,(H2,21,22,23) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II)) | BDBM340876
(3-(dibenzo[b,d]thiophen-4-yl)-1-isopropyl-1H- pyra...)Show SMILES CC(C)n1nc(-c2cccc3c4ccccc4sc23)c2c(N)ncnc12 Show InChI InChI=1S/C20H17N5S/c1-11(2)25-20-16(19(21)22-10-23-20)17(24-25)14-8-5-7-13-12-6-3-4-9-15(12)26-18(13)14/h3-11H,1-2H3,(H2,21,22,23) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
() | BDBM340876
(3-(dibenzo[b,d]thiophen-4-yl)-1-isopropyl-1H- pyra...)Show SMILES CC(C)n1nc(-c2cccc3c4ccccc4sc23)c2c(N)ncnc12 Show InChI InChI=1S/C20H17N5S/c1-11(2)25-20-16(19(21)22-10-23-20)17(24-25)14-8-5-7-13-12-6-3-4-9-15(12)26-18(13)14/h3-11H,1-2H3,(H2,21,22,23) | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
() | BDBM340876
(3-(dibenzo[b,d]thiophen-4-yl)-1-isopropyl-1H- pyra...)Show SMILES CC(C)n1nc(-c2cccc3c4ccccc4sc23)c2c(N)ncnc12 Show InChI InChI=1S/C20H17N5S/c1-11(2)25-20-16(19(21)22-10-23-20)17(24-25)14-8-5-7-13-12-6-3-4-9-15(12)26-18(13)14/h3-11H,1-2H3,(H2,21,22,23) | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1, putative
(Cryptosporidium parvum (strain Iowa II)) | BDBM340876
(3-(dibenzo[b,d]thiophen-4-yl)-1-isopropyl-1H- pyra...)Show SMILES CC(C)n1nc(-c2cccc3c4ccccc4sc23)c2c(N)ncnc12 Show InChI InChI=1S/C20H17N5S/c1-11(2)25-20-16(19(21)22-10-23-20)17(24-25)14-8-5-7-13-12-6-3-4-9-15(12)26-18(13)14/h3-11H,1-2H3,(H2,21,22,23) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |