Found 7 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50198973
(CHEMBL396029 | N-(1-(1H-indol-3-yl)propan-2-yl)-2,...)Show SMILES CC(Cc1c[nH]c2ccccc12)NS(=O)(=O)c1c(Cl)cc(Cl)cc1Cl |w:1.0| Show InChI InChI=1S/C17H15Cl3N2O2S/c1-10(6-11-9-21-16-5-3-2-4-13(11)16)22-25(23,24)17-14(19)7-12(18)8-15(17)20/h2-5,7-10,21-22H,6H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human GR |
Bioorg Med Chem Lett 17: 315-9 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.058 BindingDB Entry DOI: 10.7270/Q2ST7QNW |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50198973
(CHEMBL396029 | N-(1-(1H-indol-3-yl)propan-2-yl)-2,...)Show SMILES CC(Cc1c[nH]c2ccccc12)NS(=O)(=O)c1c(Cl)cc(Cl)cc1Cl |w:1.0| Show InChI InChI=1S/C17H15Cl3N2O2S/c1-10(6-11-9-21-16-5-3-2-4-13(11)16)22-25(23,24)17-14(19)7-12(18)8-15(17)20/h2-5,7-10,21-22H,6H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Displacement of TAMRA-labeled dexamethasone from glucocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assay |
Bioorg Med Chem Lett 23: 6640-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5 |
More data for this Ligand-Target Pair | |
Mineralocorticoid receptor
(Homo sapiens (Human)) | BDBM50198973
(CHEMBL396029 | N-(1-(1H-indol-3-yl)propan-2-yl)-2,...)Show SMILES CC(Cc1c[nH]c2ccccc12)NS(=O)(=O)c1c(Cl)cc(Cl)cc1Cl |w:1.0| Show InChI InChI=1S/C17H15Cl3N2O2S/c1-10(6-11-9-21-16-5-3-2-4-13(11)16)22-25(23,24)17-14(19)7-12(18)8-15(17)20/h2-5,7-10,21-22H,6H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human MR |
Bioorg Med Chem Lett 17: 315-9 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.058 BindingDB Entry DOI: 10.7270/Q2ST7QNW |
More data for this Ligand-Target Pair | |
Mineralocorticoid receptor
(Homo sapiens (Human)) | BDBM50198973
(CHEMBL396029 | N-(1-(1H-indol-3-yl)propan-2-yl)-2,...)Show SMILES CC(Cc1c[nH]c2ccccc12)NS(=O)(=O)c1c(Cl)cc(Cl)cc1Cl |w:1.0| Show InChI InChI=1S/C17H15Cl3N2O2S/c1-10(6-11-9-21-16-5-3-2-4-13(11)16)22-25(23,24)17-14(19)7-12(18)8-15(17)20/h2-5,7-10,21-22H,6H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Binding affinity to mineralocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assay |
Bioorg Med Chem Lett 23: 6640-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5 |
More data for this Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50198973
(CHEMBL396029 | N-(1-(1H-indol-3-yl)propan-2-yl)-2,...)Show SMILES CC(Cc1c[nH]c2ccccc12)NS(=O)(=O)c1c(Cl)cc(Cl)cc1Cl |w:1.0| Show InChI InChI=1S/C17H15Cl3N2O2S/c1-10(6-11-9-21-16-5-3-2-4-13(11)16)22-25(23,24)17-14(19)7-12(18)8-15(17)20/h2-5,7-10,21-22H,6H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of human PR |
Bioorg Med Chem Lett 17: 315-9 (2007)
Article DOI: 10.1016/j.bmcl.2006.10.058 BindingDB Entry DOI: 10.7270/Q2ST7QNW |
More data for this Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50198973
(CHEMBL396029 | N-(1-(1H-indol-3-yl)propan-2-yl)-2,...)Show SMILES CC(Cc1c[nH]c2ccccc12)NS(=O)(=O)c1c(Cl)cc(Cl)cc1Cl |w:1.0| Show InChI InChI=1S/C17H15Cl3N2O2S/c1-10(6-11-9-21-16-5-3-2-4-13(11)16)22-25(23,24)17-14(19)7-12(18)8-15(17)20/h2-5,7-10,21-22H,6H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Displacement of TAMRA-labeled mifepristone from progesterone receptor (unknown origin) by fluorescence polarization competitive binding assay |
Bioorg Med Chem Lett 23: 6640-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50198973
(CHEMBL396029 | N-(1-(1H-indol-3-yl)propan-2-yl)-2,...)Show SMILES CC(Cc1c[nH]c2ccccc12)NS(=O)(=O)c1c(Cl)cc(Cl)cc1Cl |w:1.0| Show InChI InChI=1S/C17H15Cl3N2O2S/c1-10(6-11-9-21-16-5-3-2-4-13(11)16)22-25(23,24)17-14(19)7-12(18)8-15(17)20/h2-5,7-10,21-22H,6H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 24 hrs |
Bioorg Med Chem Lett 23: 6640-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5 |
More data for this Ligand-Target Pair | |