Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 380.3 BDBM50561354

Wt: 380.3 BDBM50561359

Wt: 380.3 BDBM50561360

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50561354 (CHEMBL4784101) Show SMILES CC1Cc2[nH]c3c(F)ccc(C)c3c2CN1C(=O)c1cc([nH]n1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of human CFTR F508 deletion mutant expressed in rat FRT cells coexpressing HS-YFP assessed as increase in iodide influx pre-incubated fo...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01050 BindingDB Entry DOI: 10.7270/Q2639TFP
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50561360 (CHEMBL4741960) Show SMILES C[C@H]1Cc2[nH]c3c(F)ccc(C)c3c2CN1C(=O)c1cc([nH]n1)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of human CFTR F508 deletion mutant expressed in rat FRT cells coexpressing HS-YFP assessed as increase in iodide influx pre-incubated fo...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01050 BindingDB Entry DOI: 10.7270/Q2639TFP
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50561359 (CHEMBL4741301) Show SMILES C[C@@H]1Cc2[nH]c3c(F)ccc(C)c3c2CN1C(=O)c1cc([nH]n1)C(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of human CFTR F508 deletion mutant expressed in rat FRT cells coexpressing HS-YFP assessed as increase in iodide influx pre-incubated fo...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01050 BindingDB Entry DOI: 10.7270/Q2639TFP
					More data for this Ligand-Target Pair