Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50102502
(2,4-Diamino-5-{3-[3-benzyl-3-[2-(propionyloxy)ethy...)Show SMILES CCC(=O)OCCN(Cc1ccccc1)\N=N\c1cc(ccc1Cl)-c1c(N)nc(N)nc1CC Show InChI InChI=1S/C24H28ClN7O2/c1-3-19-22(23(26)29-24(27)28-19)17-10-11-18(25)20(14-17)30-31-32(12-13-34-21(33)4-2)15-16-8-6-5-7-9-16/h5-11,14H,3-4,12-13,15H2,1-2H3,(H4,26,27,28,29)/b31-30+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description
Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii. |
J Med Chem 44: 2555-64 (2001)
BindingDB Entry DOI: 10.7270/Q2SX6CHM |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50102502
(2,4-Diamino-5-{3-[3-benzyl-3-[2-(propionyloxy)ethy...)Show SMILES CCC(=O)OCCN(Cc1ccccc1)\N=N\c1cc(ccc1Cl)-c1c(N)nc(N)nc1CC Show InChI InChI=1S/C24H28ClN7O2/c1-3-19-22(23(26)29-24(27)28-19)17-10-11-18(25)20(14-17)30-31-32(12-13-34-21(33)4-2)15-16-8-6-5-7-9-16/h5-11,14H,3-4,12-13,15H2,1-2H3,(H4,26,27,28,29)/b31-30+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description
Inhibitory activity against dihydrofolate reductase DHFR in rat liver |
J Med Chem 44: 2555-64 (2001)
BindingDB Entry DOI: 10.7270/Q2SX6CHM |
More data for this
Ligand-Target Pair | |