Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human)) | BDBM301426
(4-amino-7-{1-[1-(3,4-difluorophenyl)-1H-1,2,3-tria...)Show SMILES CCC(c1cn(nn1)-c1ccc(F)c(F)c1)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C23H15F5N10/c1-2-13(17-9-37(36-35-17)12-3-4-15(24)16(25)5-12)19-14(6-29)18(20-21(30)33-10-34-38(19)20)11-7-31-22(32-8-11)23(26,27)28/h3-5,7-10,13H,2H2,1H3,(H2,30,33,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 41.2 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC.
US Patent
| Assay Description
Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al... |
US Patent US10131670 (2018)
BindingDB Entry DOI: 10.7270/Q29025VF |
More data for this
Ligand-Target Pair | |
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human)) | BDBM301426
(4-amino-7-{1-[1-(3,4-difluorophenyl)-1H-1,2,3-tria...)Show SMILES CCC(c1cn(nn1)-c1ccc(F)c(F)c1)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C23H15F5N10/c1-2-13(17-9-37(36-35-17)12-3-4-15(24)16(25)5-12)19-14(6-29)18(20-21(30)33-10-34-38(19)20)11-7-31-22(32-8-11)23(26,27)28/h3-5,7-10,13H,2H2,1H3,(H2,30,33,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 28.4 | n/a | n/a | n/a | n/a |
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC.
US Patent
| Assay Description
Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ... |
US Patent US10131670 (2018)
BindingDB Entry DOI: 10.7270/Q29025VF |
More data for this
Ligand-Target Pair | |