Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
(Homo sapiens (Human)) | BDBM201237
(US9187424, 5)Show SMILES CCCCOc1ccc(cc1)C1(CC(=C(C#N)C(=O)N1)c1ccc(C)cc1)C(F)(F)F |t:14| Show InChI InChI=1S/C24H23F3N2O2/c1-3-4-13-31-19-11-9-18(10-12-19)23(24(25,26)27)14-20(21(15-28)22(30)29-23)17-7-5-16(2)6-8-17/h5-12H,3-4,13-14H2,1-2H3,(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff... |
US Patent US9187424 (2015)
BindingDB Entry DOI: 10.7270/Q2FQ9VFG |
More data for this
Ligand-Target Pair | |
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
(Homo sapiens (Human)) | BDBM201237
(US9187424, 5)Show SMILES CCCCOc1ccc(cc1)C1(CC(=C(C#N)C(=O)N1)c1ccc(C)cc1)C(F)(F)F |t:14| Show InChI InChI=1S/C24H23F3N2O2/c1-3-4-13-31-19-11-9-18(10-12-19)23(24(25,26)27)14-20(21(15-28)22(30)29-23)17-7-5-16(2)6-8-17/h5-12H,3-4,13-14H2,1-2H3,(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human recombinant MGAT2 expressed in Sf9 cell membrane using 2-monooleglycerol and [H3]-oleoyl-CoA as substrates incubated for 20 mins ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01356
BindingDB Entry DOI: 10.7270/Q2RF5ZVM |
More data for this
Ligand-Target Pair | |
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
(Mus musculus) | BDBM201237
(US9187424, 5)Show SMILES CCCCOc1ccc(cc1)C1(CC(=C(C#N)C(=O)N1)c1ccc(C)cc1)C(F)(F)F |t:14| Show InChI InChI=1S/C24H23F3N2O2/c1-3-4-13-31-19-11-9-18(10-12-19)23(24(25,26)27)14-20(21(15-28)22(30)29-23)17-7-5-16(2)6-8-17/h5-12H,3-4,13-14H2,1-2H3,(H,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of mouse recombinant MGAT2 expressed in Sf9 cell membrane using 2-oleoylglycerol and oleoyl-CoA as substrates incubated for 10 mins by LCM... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01356
BindingDB Entry DOI: 10.7270/Q2RF5ZVM |
More data for this
Ligand-Target Pair | |
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
(Homo sapiens (Human)) | BDBM201237
(US9187424, 5)Show SMILES CCCCOc1ccc(cc1)C1(CC(=C(C#N)C(=O)N1)c1ccc(C)cc1)C(F)(F)F |t:14| Show InChI InChI=1S/C24H23F3N2O2/c1-3-4-13-31-19-11-9-18(10-12-19)23(24(25,26)27)14-20(21(15-28)22(30)29-23)17-7-5-16(2)6-8-17/h5-12H,3-4,13-14H2,1-2H3,(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 309 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Bristol-Myers Squibb Company
US Patent
| Assay Description
MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy... |
US Patent US9187424 (2015)
BindingDB Entry DOI: 10.7270/Q2FQ9VFG |
More data for this
Ligand-Target Pair | |