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Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 498.5
BDBM50006812

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Wt: 497.5
BDBM50021024

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 21 hits in this display
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cysteinyl leukotriene receptor 1 (GUINEA PIG)	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	510	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rorer Central Research Curated by ChEMBL					Assay Description Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)				J Med Chem 33: 1194-200 (1990) BindingDB Entry DOI: 10.7270/Q2PK0F4V
Rorer Central Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1 (GUINEA PIG)	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	510	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rhone-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Binding affinity against LTD4 receptor in guinea pig lung membranes.				J Med Chem 34: 1704-7 (1991) BindingDB Entry DOI: 10.7270/Q2FJ2FR5
Rhone-Poulenc Rorer Central Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1 (GUINEA PIG)	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ICI Pharmaceuticals Group Curated by ChEMBL					Assay Description Compound was evaluated for its ability to displace [3H]-LTD4 from LTD4 receptor in guinea pig lung membranes				J Med Chem 34: 1235-42 (1991) BindingDB Entry DOI: 10.7270/Q2K936HB
ICI Pharmaceuticals Group Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1 (GUINEA PIG)	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	940	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rorer Central Research Curated by ChEMBL					Assay Description Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)				J Med Chem 33: 1186-94 (1990) BindingDB Entry DOI: 10.7270/Q2TB15WM
Rorer Central Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1/2 (Homo sapiens (Human))	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rorer Central Research Curated by ChEMBL					Assay Description In vitro binding affinity against cysteinyl leukotriene D4 receptor from guinea pig lung membrane				J Med Chem 33: 2828-41 (1990) BindingDB Entry DOI: 10.7270/Q29C6WDM
Rorer Central Research Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1 (GUINEA PIG)	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against Cysteinyl leukotriene D4 receptor in guinea pig lung membranes using [3H]-LTD4 as the radioligand.				J Med Chem 30: 959-61 (1987) BindingDB Entry DOI: 10.7270/Q2D50KZN
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1/2 (Homo sapiens (Human))	BDBM50021024 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	2.01E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound is evaluated for its ability to inhibit [3H]LTD4 binding to Cysteinyl leukotriene D4 receptor in guinea pig lung membranes				J Med Chem 29: 1442-52 (1986) BindingDB Entry DOI: 10.7270/Q2S75JHD
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1 (GUINEA PIG)	BDBM50021024 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding constant was determined as affinity to displace [3H]-LTD4 from Cysteinyl leukotriene D4 receptor on guinea pig lung membrane				J Med Chem 28: 1145-7 (1985) BindingDB Entry DOI: 10.7270/Q26M35V3
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1/2 (Homo sapiens (Human))	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of SRS-A-induced contractions in guinea pig ileum				J Med Chem 30: 173-8 (1987) BindingDB Entry DOI: 10.7270/Q2D220TJ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1/2 (Homo sapiens (Human))	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of LTD4-induced contraction in guinea pig ileum				J Med Chem 30: 911-8 (1987) BindingDB Entry DOI: 10.7270/Q25X2B45
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1/2 (Homo sapiens (Human))	BDBM50021024 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileum				J Med Chem 31: 84-91 (1988) BindingDB Entry DOI: 10.7270/Q20K2BSP
Ono Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1/2 (Homo sapiens (Human))	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Rorer Central Research Curated by ChEMBL					Assay Description Inhibition of the spasmogenic activity of LTD4 in guinea pig parenchymal strips.				J Med Chem 33: 1186-94 (1990) BindingDB Entry DOI: 10.7270/Q2TB15WM
Rorer Central Research Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co. Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.				J Med Chem 36: 3765-70 (1994) BindingDB Entry DOI: 10.7270/Q279459H
Eisai Co. Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1 (Homo sapiens (Human))	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Compound was tested for binding affinity against Cysteinyl leukotriene D4 receptor				J Med Chem 39: 2629-54 (1996) Article DOI: 10.1021/jm960088k BindingDB Entry DOI: 10.7270/Q21J9BFT
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1/2 (Homo sapiens (Human))	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibitory activity to block binding of [3H]leukotriene D4 to LTD4 receptor sites in homogenized guinea pig lung				J Med Chem 32: 1842-60 (1989) BindingDB Entry DOI: 10.7270/Q28W3C8B
Roche Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Thromboxane-A synthase (Homo sapiens (Human))	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human platelet thromboxane synthase (TXA2) was determined in human platelets				J Med Chem 30: 185-93 (1987) BindingDB Entry DOI: 10.7270/Q2222VBH
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats				Drug Metab Dispos 40: 2332-41 (2012) Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus)	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description The compound was tested for inhibitory activity against 5-lipoxygenase in rat RBL-1 cells				J Med Chem 35: 2501-24 (1992) BindingDB Entry DOI: 10.7270/Q23B60R4
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (BOVINE)	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of bovine heart Phosphodiesterase 1A				J Med Chem 32: 1842-60 (1989) BindingDB Entry DOI: 10.7270/Q28W3C8B
Roche Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1 (GUINEA PIG)	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Curated by ChEMBL					Assay Description Dissociation constant was determined against Cysteinyl leukotriene D4 receptor of guinea pig lung membranes using radioligand binding assays.				J Med Chem 38: 2472-7 (1995) BindingDB Entry DOI: 10.7270/Q2VT1R3G
Vrije Universiteit Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteinyl leukotriene receptor 1/2 (Homo sapiens (Human))	BDBM50006812 (7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Curated by ChEMBL					Assay Description Displacement of [3H]LTD4 from Cysteinyl leukotriene D4 receptor in guinea pig lung membranes				J Med Chem 40: 1075-89 (1997) Article DOI: 10.1021/jm960628d BindingDB Entry DOI: 10.7270/Q25141XJ
Vrije Universiteit Curated by ChEMBL					More data for this Ligand-Target Pair