Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50163105
((R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline...)Show InChI InChI=1S/C12H17FN2O2S/c1-2-15-18(16,17)12-4-3-9-5-11(7-13)14-8-10(9)6-12/h3-4,6,11,14-15H,2,5,7-8H2,1H3/t11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 750 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description In vitro binding affinity against recombinant human Phenylethanolamine N-methyltransferase expressed in E. coli using [methyl-3H]-AdoMet |
J Med Chem 48: 1806-12 (2005)
Article DOI: 10.1021/jm049594x BindingDB Entry DOI: 10.7270/Q2TX3DW4 |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Alpha-2A adrenergic receptor [16-465]
(Rattus norvegicus (rat)) | BDBM50163105
((R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline...)Show InChI InChI=1S/C12H17FN2O2S/c1-2-15-18(16,17)12-4-3-9-5-11(7-13)14-8-10(9)6-12/h3-4,6,11,14-15H,2,5,7-8H2,1H3/t11-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description In vitro binding affinity against rat Alpha-2 adrenergic receptor using [3H]-clonidine |
J Med Chem 48: 1806-12 (2005)
Article DOI: 10.1021/jm049594x BindingDB Entry DOI: 10.7270/Q2TX3DW4 |
More data for this Ligand-Target Pair | |