Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity protein kinase CLK1
(Homo sapiens (Human)) | BDBM50234812
(CHEMBL4078755)Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cc3ccccc3s2)c1 Show InChI InChI=1S/C20H18N2O4S2/c1-3-28(23,24)14-8-9-16(25-2)15(11-14)22-20-21-12-17(26-20)19-10-13-6-4-5-7-18(13)27-19/h4-12H,3H2,1-2H3,(H,21,22) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Comenius University in Bratislava
Curated by ChEMBL
| Assay Description Inhibition of human CLK1 using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation counting |
Eur J Med Chem 126: 754-761 (2017)
Article DOI: 10.1016/j.ejmech.2016.11.003 BindingDB Entry DOI: 10.7270/Q2S75JJV |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50234812
(CHEMBL4078755)Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cc3ccccc3s2)c1 Show InChI InChI=1S/C20H18N2O4S2/c1-3-28(23,24)14-8-9-16(25-2)15(11-14)22-20-21-12-17(26-20)19-10-13-6-4-5-7-18(13)27-19/h4-12H,3H2,1-2H3,(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Comenius University in Bratislava
Curated by ChEMBL
| Assay Description Inhibition of DYRK1A (unknown origin) using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation counting |
Eur J Med Chem 126: 754-761 (2017)
Article DOI: 10.1016/j.ejmech.2016.11.003 BindingDB Entry DOI: 10.7270/Q2S75JJV |
More data for this Ligand-Target Pair | |