Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 394.8 BDBM50128230

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128230 (CHEMBL3628096) Show SMILES CCc1ccc(o1)C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C21H15ClN2O4/c1-2-13-8-10-18(28-13)19(25)23-12-7-9-17(16(22)11-12)24-20(26)14-5-3-4-6-15(14)21(24)27/h3-11H,2H2,1H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50128230 (CHEMBL3628096) Show SMILES CCc1ccc(o1)C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1 Show InChI InChI=1S/C21H15ClN2O4/c1-2-13-8-10-18(28-13)19(25)23-12-7-9-17(16(22)11-12)24-20(26)14-5-3-4-6-15(14)21(24)27/h3-11H,2H2,1H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...				J Med Chem 58: 7959-71 (2015) Article DOI: 10.1021/acs.jmedchem.5b00727 BindingDB Entry DOI: 10.7270/Q2MK6FQ4
					More data for this Ligand-Target Pair