Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Proline-rich AKT1 substrate 1
(Homo sapiens (Human)) | BDBM386000
(US10287300, Compound A7 | {2-(4-Chlorophenyl)-2-[4...)Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H27ClN6/c1-25(2)13-18(15-3-5-16(21)6-4-15)26-9-11-27(12-10-26)20-17-7-8-22-19(17)23-14-24-20/h3-6,14,18H,7-13H2,1-2H3,(H,22,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description
A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this
Ligand-Target Pair | |
Ribosomal protein S6 kinase beta-1 [T412E]
(Homo sapiens (Human)) | BDBM386000
(US10287300, Compound A7 | {2-(4-Chlorophenyl)-2-[4...)Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H27ClN6/c1-25(2)13-18(15-3-5-16(21)6-4-15)26-9-11-27(12-10-26)20-17-7-8-22-19(17)23-14-24-20/h3-6,14,18H,7-13H2,1-2H3,(H,22,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin at Madison
| Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com... |
J Med Chem 51: 7243-52 (2008)
BindingDB Entry DOI: 10.7270/Q26M394B |
More data for this
Ligand-Target Pair | |