| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proline-rich AKT1 substrate 1 |
|---|
| Ligand | BDBM386000 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | AKT Enzyme Assay |
|---|
| IC50 | 300±n/a nM |
|---|
| Citation |  Lan, R; Huck, BR; Chen, X; Xiao, Y Heterocyclic derivatives as modulators of kinase activity US Patent US10287300 Publication Date 5/14/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Proline-rich AKT1 substrate 1 |
|---|
| Name: | Proline-rich AKT1 substrate 1 |
|---|
| Synonyms: | 40 kDa proline-rich AKT substrate | AKT1S1 | AKTS1_HUMAN | PRAS40 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 27368.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_664853 |
|---|
| Residue: | 256 |
|---|
| Sequence: | MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARR
CLHDIALAHRAATAARPPAPPPAPQPPSPTPSPPRPTLAREDNEEDEDEPTETETSGEQL
GISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSVPPASALPTQQY
AKSLPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLP
RPRLNTSDFQKLKRKY
|
|
|
|---|
| BDBM386000 |
|---|
| n/a |
|---|
| Name | BDBM386000 |
|---|
| Synonyms: | US10287300, Compound A7 | {2-(4-Chlorophenyl)-2-[4-(6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-ethyl}-dimethylamine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H27ClN6 |
|---|
| Mol. Mass. | 386.922 |
|---|
| SMILES | CN(C)CC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
