Found 6 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM161912
(US10017516, Compound 44 | US9682983, 44)Show SMILES CN1CCN(CCOc2ccc(cn2)-c2cnc3c(cnn3c2)-c2cccc3ncccc23)CC1 Show InChI InChI=1S/C27H27N7O/c1-32-10-12-33(13-11-32)14-15-35-26-8-7-20(16-29-26)21-17-30-27-24(18-31-34(27)19-21)22-4-2-6-25-23(22)5-3-9-28-25/h2-9,16-19H,10-15H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc.
US Patent
| Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... |
US Patent US10017516 (2018)
BindingDB Entry DOI: 10.7270/Q20P12CN |
More data for this Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM161912
(US10017516, Compound 44 | US9682983, 44)Show SMILES CN1CCN(CCOc2ccc(cn2)-c2cnc3c(cnn3c2)-c2cccc3ncccc23)CC1 Show InChI InChI=1S/C27H27N7O/c1-32-10-12-33(13-11-32)14-15-35-26-8-7-20(16-29-26)21-17-30-27-24(18-31-34(27)19-21)22-4-2-6-25-23(22)5-3-9-28-25/h2-9,16-19H,10-15H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health
US Patent
| Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... |
US Patent US9682983 (2017)
BindingDB Entry DOI: 10.7270/Q28S4N3R |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase receptor R3
(Homo sapiens (Human)) | BDBM161912
(US10017516, Compound 44 | US9682983, 44)Show SMILES CN1CCN(CCOc2ccc(cn2)-c2cnc3c(cnn3c2)-c2cccc3ncccc23)CC1 Show InChI InChI=1S/C27H27N7O/c1-32-10-12-33(13-11-32)14-15-35-26-8-7-20(16-29-26)21-17-30-27-24(18-31-34(27)19-21)22-4-2-6-25-23(22)5-3-9-28-25/h2-9,16-19H,10-15H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 521 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health
US Patent
| Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... |
US Patent US9682983 (2017)
BindingDB Entry DOI: 10.7270/Q28S4N3R |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase receptor R3
(Homo sapiens (Human)) | BDBM161912
(US10017516, Compound 44 | US9682983, 44)Show SMILES CN1CCN(CCOc2ccc(cn2)-c2cnc3c(cnn3c2)-c2cccc3ncccc23)CC1 Show InChI InChI=1S/C27H27N7O/c1-32-10-12-33(13-11-32)14-15-35-26-8-7-20(16-29-26)21-17-30-27-24(18-31-34(27)19-21)22-4-2-6-25-23(22)5-3-9-28-25/h2-9,16-19H,10-15H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 521 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc.
US Patent
| Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... |
US Patent US10017516 (2018)
BindingDB Entry DOI: 10.7270/Q20P12CN |
More data for this Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B
(Homo sapiens (Human)) | BDBM161912
(US10017516, Compound 44 | US9682983, 44)Show SMILES CN1CCN(CCOc2ccc(cn2)-c2cnc3c(cnn3c2)-c2cccc3ncccc23)CC1 Show InChI InChI=1S/C27H27N7O/c1-32-10-12-33(13-11-32)14-15-35-26-8-7-20(16-29-26)21-17-30-27-24(18-31-34(27)19-21)22-4-2-6-25-23(22)5-3-9-28-25/h2-9,16-19H,10-15H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc.
US Patent
| Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... |
US Patent US10017516 (2018)
BindingDB Entry DOI: 10.7270/Q20P12CN |
More data for this Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B
(Homo sapiens (Human)) | BDBM161912
(US10017516, Compound 44 | US9682983, 44)Show SMILES CN1CCN(CCOc2ccc(cn2)-c2cnc3c(cnn3c2)-c2cccc3ncccc23)CC1 Show InChI InChI=1S/C27H27N7O/c1-32-10-12-33(13-11-32)14-15-35-26-8-7-20(16-29-26)21-17-30-27-24(18-31-34(27)19-21)22-4-2-6-25-23(22)5-3-9-28-25/h2-9,16-19H,10-15H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health
US Patent
| Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... |
US Patent US9682983 (2017)
BindingDB Entry DOI: 10.7270/Q28S4N3R |
More data for this Ligand-Target Pair | |