Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 372.3 BDBM182705

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM182705 (US9145402, 11) Show SMILES CNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OC)ncc1C#N Show InChI InChI=1S/C18H21FN6O2/c1-21-17-13(9-20)10-22-18(24-17)23-15-8-14(19)12(7-16(15)26-2)11-25-3-5-27-6-4-25/h7-8,10H,3-6,11H2,1-2H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
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