Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150595
(US10238633, Example 269 | US8987249, 269 | US97136...)Show SMILES CO[C@@H]1C[C@@H]2CN(CCN2C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C24H32FN5O2/c1-32-21-10-20-13-29(6-7-30(20)14-21)19-5-3-15(22(25)11-19)8-18(12-26)28-24(31)23-16-2-4-17(9-16)27-23/h3,5,11,16-18,20-21,23,27H,2,4,6-10,13-14H2,1H3,(H,28,31)/t16-,17+,18-,20+,21+,23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation
| Assay Description The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in a 1:2 ratio with ... |
J Med Chem 50: 984-1000 (2007)
BindingDB Entry DOI: 10.7270/Q22R3TZF |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150595
(US10238633, Example 269 | US8987249, 269 | US97136...)Show SMILES CO[C@@H]1C[C@@H]2CN(CCN2C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C24H32FN5O2/c1-32-21-10-20-13-29(6-7-30(20)14-21)19-5-3-15(22(25)11-19)8-18(12-26)28-24(31)23-16-2-4-17(9-16)27-23/h3,5,11,16-18,20-21,23,27H,2,4,6-10,13-14H2,1H3,(H,28,31)/t16-,17+,18-,20+,21+,23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | 6.0 | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod.... |
US Patent US9713606 (2017)
BindingDB Entry DOI: 10.7270/Q21G0P8M |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150595
(US10238633, Example 269 | US8987249, 269 | US97136...)Show SMILES CO[C@@H]1C[C@@H]2CN(CCN2C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C24H32FN5O2/c1-32-21-10-20-13-29(6-7-30(20)14-21)19-5-3-15(22(25)11-19)8-18(12-26)28-24(31)23-16-2-4-17(9-16)27-23/h3,5,11,16-18,20-21,23,27H,2,4,6-10,13-14H2,1H3,(H,28,31)/t16-,17+,18-,20+,21+,23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 ug/ml, respectively), and then activated by mixing in a 1:2 ratio with a Cys... |
US Patent US8987249 (2015)
BindingDB Entry DOI: 10.7270/Q2KP80WG |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM150595
(US10238633, Example 269 | US8987249, 269 | US97136...)Show SMILES CO[C@@H]1C[C@@H]2CN(CCN2C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C24H32FN5O2/c1-32-21-10-20-13-29(6-7-30(20)14-21)19-5-3-15(22(25)11-19)8-18(12-26)28-24(31)23-16-2-4-17(9-16)27-23/h3,5,11,16-18,20-21,23,27H,2,4,6-10,13-14H2,1H3,(H,28,31)/t16-,17+,18-,20+,21+,23-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation
| Assay Description To activate the proenzyme, 5 μl procathepsin K were mixed with 1 ul activation buffer, and incubated at room temperature for 30 min.5 μL te... |
J Med Chem 50: 984-1000 (2007)
BindingDB Entry DOI: 10.7270/Q22R3TZF |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM150595
(US10238633, Example 269 | US8987249, 269 | US97136...)Show SMILES CO[C@@H]1C[C@@H]2CN(CCN2C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C24H32FN5O2/c1-32-21-10-20-13-29(6-7-30(20)14-21)19-5-3-15(22(25)11-19)8-18(12-26)28-24(31)23-16-2-4-17(9-16)27-23/h3,5,11,16-18,20-21,23,27H,2,4,6-10,13-14H2,1H3,(H,28,31)/t16-,17+,18-,20+,21+,23-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | 3.5 | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr... |
US Patent US9713606 (2017)
BindingDB Entry DOI: 10.7270/Q21G0P8M |
More data for this Ligand-Target Pair | |