Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50082874
(1-{5-[4-(2-Carbamoyl-phenyl)-piperazin-1-yl]-penty...)Show SMILES COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCN(CC2)c2ccccc2C(N)=O)C1c1ccc(F)c(F)c1 |c:4,t:7| Show InChI InChI=1S/C30H37F2N5O3/c1-20-27(30(39)40-3)28(22-11-12-24(31)25(32)19-22)37(21(2)34-20)14-8-4-7-13-35-15-17-36(18-16-35)26-10-6-5-9-23(26)29(33)38/h5-6,9-12,19,28H,4,7-8,13-18H2,1-3H3,(H2,33,38) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation
Curated by ChEMBL
| Assay Description Binding affinity against Alpha-1A adrenergic receptor (recombinant human receptor) using [3H]prazosin. |
J Med Chem 42: 4804-13 (1999)
BindingDB Entry DOI: 10.7270/Q2RJ4K5R |
More data for this Ligand-Target Pair | |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50082874
(1-{5-[4-(2-Carbamoyl-phenyl)-piperazin-1-yl]-penty...)Show SMILES COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCN(CC2)c2ccccc2C(N)=O)C1c1ccc(F)c(F)c1 |c:4,t:7| Show InChI InChI=1S/C30H37F2N5O3/c1-20-27(30(39)40-3)28(22-11-12-24(31)25(32)19-22)37(21(2)34-20)14-8-4-7-13-35-15-17-36(18-16-35)26-10-6-5-9-23(26)29(33)38/h5-6,9-12,19,28H,4,7-8,13-18H2,1-3H3,(H2,33,38) | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation
Curated by ChEMBL
| Assay Description Binding affinity against Alpha-1B adrenergic receptor (recombinant human receptor) using [3H]prazosin. |
J Med Chem 42: 4804-13 (1999)
BindingDB Entry DOI: 10.7270/Q2RJ4K5R |
More data for this Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Homo sapiens (Human)) | BDBM50082874
(1-{5-[4-(2-Carbamoyl-phenyl)-piperazin-1-yl]-penty...)Show SMILES COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCN(CC2)c2ccccc2C(N)=O)C1c1ccc(F)c(F)c1 |c:4,t:7| Show InChI InChI=1S/C30H37F2N5O3/c1-20-27(30(39)40-3)28(22-11-12-24(31)25(32)19-22)37(21(2)34-20)14-8-4-7-13-35-15-17-36(18-16-35)26-10-6-5-9-23(26)29(33)38/h5-6,9-12,19,28H,4,7-8,13-18H2,1-3H3,(H2,33,38) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 580 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation
Curated by ChEMBL
| Assay Description Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin. |
J Med Chem 42: 4804-13 (1999)
BindingDB Entry DOI: 10.7270/Q2RJ4K5R |
More data for this Ligand-Target Pair | |