Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 533.6 BDBM435368

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM435368 (US10568876, Example 128 | methyl 3-(2-(1- cyanocyc...) Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)C1(CC1)C#N Show InChI InChI=1S/C33H31N3O4/c1-40-31(38)23-9-5-8-22(16-23)25-11-10-24(18-35-30(37)28-17-27(28)21-6-3-2-4-7-21)29-19-36(15-12-26(25)29)32(39)33(20-34)13-14-33/h2-11,16,27-28H,12-15,17-19H2,1H3,(H,35,37)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US10568876 (2020) BindingDB Entry DOI: 10.7270/Q22B91FB
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