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Target
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Compile Data Set for Download or QSAR
Marvin 2D Structure
The following exact ligands are found in BindingDB
Wt: 594.6
BDBM50577131
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Proteasome subunit beta type-8
(Homo sapiens (Human))
BDBM50577131
(CHEMBL4855915)
Show SMILES
COC1CCN(CC1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
26
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human proteasome subunit beta-5i chymotrypsin like activity using SUC-ANW-AMC as flurogenic substrate preincubated for 15 mins followed...
Citation and Details
Article DOI:
10.1016/j.ejmech.2021.113556
BindingDB Entry DOI:
10.7270/Q2BR8WZN
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5
(Homo sapiens (Human))
BDBM50577131
(CHEMBL4855915)
Show SMILES
COC1CCN(CC1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
647
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of chymotrypsin-like activity of human 20s proteasome beta 5c subunit using suc-WLA-AMC as flurogenic substrate preincubated for 15 mins f...
Citation and Details
Article DOI:
10.1016/j.ejmech.2021.113556
BindingDB Entry DOI:
10.7270/Q2BR8WZN
More data for this
Ligand-Target Pair
Proteasome subunit beta type-9
(Homo sapiens (Human))
BDBM50577131
(CHEMBL4855915)
Show SMILES
COC1CCN(CC1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
5.77E+3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human caspase-like activity of 20s proteasome beta 1i subunit using SUC-PAL-AMC as flurogenic substrate preincubated for 15 mins follow...
Citation and Details
Article DOI:
10.1016/j.ejmech.2021.113556
BindingDB Entry DOI:
10.7270/Q2BR8WZN
More data for this
Ligand-Target Pair
Proteasome subunit beta type-4
(Homo sapiens (Human))
BDBM50577131
(CHEMBL4855915)
Show SMILES
COC1CCN(CC1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>1.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human trypsin-like activity of 20s proteasome beta 2c subunit using SUC-KQL-AMC as flurogenic substrate preincubated for 15 mins follow...
Citation and Details
Article DOI:
10.1016/j.ejmech.2021.113556
BindingDB Entry DOI:
10.7270/Q2BR8WZN
More data for this
Ligand-Target Pair
Proteasome subunit beta type-10
(Homo sapiens (Human))
BDBM50577131
(CHEMBL4855915)
Show SMILES
COC1CCN(CC1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>1.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human trypsin-like activity of 20s proteasome beta 2i subunit using SUC-VGR-AMC as flurogenic substrate preincubated for 15 mins follow...
Citation and Details
Article DOI:
10.1016/j.ejmech.2021.113556
BindingDB Entry DOI:
10.7270/Q2BR8WZN
More data for this
Ligand-Target Pair
Proteasome subunit alpha type-1
(Homo sapiens (Human))
BDBM50577131
(CHEMBL4855915)
Show SMILES
COC1CCN(CC1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>1.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of caspase-like activity of human proteasome beta-1c subunit using SUC-LLE-AMC as flurogenic substrate preincubated for 15 mins followed b...
Citation and Details
Article DOI:
10.1016/j.ejmech.2021.113556
BindingDB Entry DOI:
10.7270/Q2BR8WZN
More data for this
Ligand-Target Pair