Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dihydrofolate reductase
(Mycobacterium avium) | BDBM50064046
(7-(3,5-Dimethoxy-benzyl)-5,6,7,8-tetrahydro-pyrido...)Show SMILES COc1cc(CN2CCc3c(C2)oc2nc(N)nc(N)c32)cc(OC)c1 Show InChI InChI=1S/C18H21N5O3/c1-24-11-5-10(6-12(7-11)25-2)8-23-4-3-13-14(9-23)26-17-15(13)16(19)21-18(20)22-17/h5-7H,3-4,8-9H2,1-2H3,(H4,19,20,21,22) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description
Inhibitory concentration was evaluated against CCRF-CEM Dihydrofolate reductase enzyme in M. avium. |
J Med Chem 41: 1409-16 (1998)
Article DOI: 10.1021/jm9705420
BindingDB Entry DOI: 10.7270/Q2513XB9 |
More data for this
Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50064046
(7-(3,5-Dimethoxy-benzyl)-5,6,7,8-tetrahydro-pyrido...)Show SMILES COc1cc(CN2CCc3c(C2)oc2nc(N)nc(N)c32)cc(OC)c1 Show InChI InChI=1S/C18H21N5O3/c1-24-11-5-10(6-12(7-11)25-2)8-23-4-3-13-14(9-23)26-17-15(13)16(19)21-18(20)22-17/h5-7H,3-4,8-9H2,1-2H3,(H4,19,20,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description
Inhibition of T. gondii Dihydrofolate reductase |
J Med Chem 41: 1409-16 (1998)
Article DOI: 10.1021/jm9705420
BindingDB Entry DOI: 10.7270/Q2513XB9 |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50064046
(7-(3,5-Dimethoxy-benzyl)-5,6,7,8-tetrahydro-pyrido...)Show SMILES COc1cc(CN2CCc3c(C2)oc2nc(N)nc(N)c32)cc(OC)c1 Show InChI InChI=1S/C18H21N5O3/c1-24-11-5-10(6-12(7-11)25-2)8-23-4-3-13-14(9-23)26-17-15(13)16(19)21-18(20)22-17/h5-7H,3-4,8-9H2,1-2H3,(H4,19,20,21,22) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description
Inhibition of P. carinii dihydrofolate reductase |
J Med Chem 41: 1409-16 (1998)
Article DOI: 10.1021/jm9705420
BindingDB Entry DOI: 10.7270/Q2513XB9 |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50064046
(7-(3,5-Dimethoxy-benzyl)-5,6,7,8-tetrahydro-pyrido...)Show SMILES COc1cc(CN2CCc3c(C2)oc2nc(N)nc(N)c32)cc(OC)c1 Show InChI InChI=1S/C18H21N5O3/c1-24-11-5-10(6-12(7-11)25-2)8-23-4-3-13-14(9-23)26-17-15(13)16(19)21-18(20)22-17/h5-7H,3-4,8-9H2,1-2H3,(H4,19,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University
Curated by ChEMBL
| Assay Description
Inhibition of Dihydrofolate reductase of rat liver |
J Med Chem 41: 1409-16 (1998)
Article DOI: 10.1021/jm9705420
BindingDB Entry DOI: 10.7270/Q2513XB9 |
More data for this
Ligand-Target Pair | |