Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dihydrofolate reductase
(Escherichia coli) | BDBM50405998
(CHEMBL300114)Show InChI InChI=1S/C13H16N4O4S/c1-20-10-4-3-8(6-11(10)21-22(2,18)19)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17) | MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Beijing Medical University
Curated by ChEMBL
| Assay Description Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductase |
J Med Chem 31: 366-70 (1988)
BindingDB Entry DOI: 10.7270/Q2BV7JTC |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase type 1
(Escherichia coli) | BDBM50405998
(CHEMBL300114)Show InChI InChI=1S/C13H16N4O4S/c1-20-10-4-3-8(6-11(10)21-22(2,18)19)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College
Curated by ChEMBL
| Assay Description Inhibitory activity against Escherichia coli dihydrofolate reductase |
J Med Chem 34: 46-54 (1991)
BindingDB Entry DOI: 10.7270/Q2X92CH4 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Lactobacillus casei) | BDBM50405998
(CHEMBL300114)Show InChI InChI=1S/C13H16N4O4S/c1-20-10-4-3-8(6-11(10)21-22(2,18)19)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 214 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College
Curated by ChEMBL
| Assay Description Inhibitory activity against Lactobacillus casei dihydrofolate reductase |
J Med Chem 32: 1895-905 (1989)
BindingDB Entry DOI: 10.7270/Q2QR4ZB9 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405998
(CHEMBL300114)Show InChI InChI=1S/C13H16N4O4S/c1-20-10-4-3-8(6-11(10)21-22(2,18)19)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College
Curated by ChEMBL
| Assay Description Inhibitory activity against chicken liver dihydrofolate reductase |
J Med Chem 32: 1895-905 (1989)
BindingDB Entry DOI: 10.7270/Q2QR4ZB9 |
More data for this Ligand-Target Pair | |