Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50097864
(CHEMBL3589675)Show SMILES COc1ccc(cc1)-c1ccc2nc(C(O)=O)c3c4cccc(Cl)c4[nH]c3c2c1 Show InChI InChI=1S/C23H15ClN2O3/c1-29-14-8-5-12(6-9-14)13-7-10-18-16(11-13)21-19(22(25-18)23(27)28)15-3-2-4-17(24)20(15)26-21/h2-11,26H,1H3,(H,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Braunschweig
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DYRK1A expressed in Escherichia coli using RS peptide as substrate |
J Med Chem 58: 3131-43 (2015)
Article DOI: 10.1021/jm501994d BindingDB Entry DOI: 10.7270/Q2736SPK |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Mus musculus) | BDBM50097864
(CHEMBL3589675)Show SMILES COc1ccc(cc1)-c1ccc2nc(C(O)=O)c3c4cccc(Cl)c4[nH]c3c2c1 Show InChI InChI=1S/C23H15ClN2O3/c1-29-14-8-5-12(6-9-14)13-7-10-18-16(11-13)21-19(22(25-18)23(27)28)15-3-2-4-17(24)20(15)26-21/h2-11,26H,1H3,(H,27,28) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Braunschweig
Curated by ChEMBL
| Assay Description Inhibition of mouse recombinant CLK1 expressed in Escherichia coli using RS peptide as substrate after 30 mins by scintillation counting analysis |
J Med Chem 58: 3131-43 (2015)
Article DOI: 10.1021/jm501994d BindingDB Entry DOI: 10.7270/Q2736SPK |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 5
(Homo sapiens (Human)) | BDBM50097864
(CHEMBL3589675)Show SMILES COc1ccc(cc1)-c1ccc2nc(C(O)=O)c3c4cccc(Cl)c4[nH]c3c2c1 Show InChI InChI=1S/C23H15ClN2O3/c1-29-14-8-5-12(6-9-14)13-7-10-18-16(11-13)21-19(22(25-18)23(27)28)15-3-2-4-17(24)20(15)26-21/h2-11,26H,1H3,(H,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Braunschweig
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK5 using [gamma-33P]ATP as substrate after 30 mins by scintillation counting analysis |
J Med Chem 58: 3131-43 (2015)
Article DOI: 10.1021/jm501994d BindingDB Entry DOI: 10.7270/Q2736SPK |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM50097864
(CHEMBL3589675)Show SMILES COc1ccc(cc1)-c1ccc2nc(C(O)=O)c3c4cccc(Cl)c4[nH]c3c2c1 Show InChI InChI=1S/C23H15ClN2O3/c1-29-14-8-5-12(6-9-14)13-7-10-18-16(11-13)21-19(22(25-18)23(27)28)15-3-2-4-17(24)20(15)26-21/h2-11,26H,1H3,(H,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Braunschweig
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK9 expressed in insect cells using CDK7/9 tide as substrate after 30 mins by scintillation counting analysis |
J Med Chem 58: 3131-43 (2015)
Article DOI: 10.1021/jm501994d BindingDB Entry DOI: 10.7270/Q2736SPK |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50097864
(CHEMBL3589675)Show SMILES COc1ccc(cc1)-c1ccc2nc(C(O)=O)c3c4cccc(Cl)c4[nH]c3c2c1 Show InChI InChI=1S/C23H15ClN2O3/c1-29-14-8-5-12(6-9-14)13-7-10-18-16(11-13)21-19(22(25-18)23(27)28)15-3-2-4-17(24)20(15)26-21/h2-11,26H,1H3,(H,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Braunschweig
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK2 using [gamma-33P]ATP as substrate after 30 mins by scintillation counting analysis |
J Med Chem 58: 3131-43 (2015)
Article DOI: 10.1021/jm501994d BindingDB Entry DOI: 10.7270/Q2736SPK |
More data for this Ligand-Target Pair | |