Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Plasmepsin II
(Plasmodium falciparum) | BDBM234535
(US9353089, 221)Show SMILES COc1ccc(cc1)C1(NC(=N)N(CC2CCCCC2)C1=O)c1ccc(OC)cc1 Show InChI InChI=1S/C24H29N3O3/c1-29-20-12-8-18(9-13-20)24(19-10-14-21(30-2)15-11-19)22(28)27(23(25)26-24)16-17-6-4-3-5-7-17/h8-15,17H,3-7,16H2,1-2H3,(H2,25,26) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.39 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Saint Louis University; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
US Patent
| Assay Description Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and... |
US Patent US9353089 (2016)
BindingDB Entry DOI: 10.7270/Q2GQ6WP6 |
More data for this Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM234535
(US9353089, 221)Show SMILES COc1ccc(cc1)C1(NC(=N)N(CC2CCCCC2)C1=O)c1ccc(OC)cc1 Show InChI InChI=1S/C24H29N3O3/c1-29-20-12-8-18(9-13-20)24(19-10-14-21(30-2)15-11-19)22(28)27(23(25)26-24)16-17-6-4-3-5-7-17/h8-15,17H,3-7,16H2,1-2H3,(H2,25,26) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6.01E+3 | n/a | n/a | n/a | n/a | 4.0 | 25 |
Saint Louis University; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
US Patent
| Assay Description The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res... |
US Patent US9353089 (2016)
BindingDB Entry DOI: 10.7270/Q2GQ6WP6 |
More data for this Ligand-Target Pair | |