Found 10 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM315509
(US10172858, Table 2.5 | US10544104, Compound 27 | ...)Show SMILES COc1ccc2[nH]c(cc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C17H18N6O/c1-9(2)23-17-14(16(18)19-8-20-17)15(22-23)13-7-10-6-11(24-3)4-5-12(10)21-13/h4-9,21H,1-3H3,(H2,18,19,20) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 56.9 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description
Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM315509
(US10172858, Table 2.5 | US10544104, Compound 27 | ...)Show SMILES COc1ccc2[nH]c(cc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C17H18N6O/c1-9(2)23-17-14(16(18)19-8-20-17)15(22-23)13-7-10-6-11(24-3)4-5-12(10)21-13/h4-9,21H,1-3H3,(H2,18,19,20) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 56.9 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
() | BDBM315509
(US10172858, Table 2.5 | US10544104, Compound 27 | ...)Show SMILES COc1ccc2[nH]c(cc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C17H18N6O/c1-9(2)23-17-14(16(18)19-8-20-17)15(22-23)13-7-10-6-11(24-3)4-5-12(10)21-13/h4-9,21H,1-3H3,(H2,18,19,20) | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 56.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM315509
(US10172858, Table 2.5 | US10544104, Compound 27 | ...)Show SMILES COc1ccc2[nH]c(cc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C17H18N6O/c1-9(2)23-17-14(16(18)19-8-20-17)15(22-23)13-7-10-6-11(24-3)4-5-12(10)21-13/h4-9,21H,1-3H3,(H2,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >500 | n/a | n/a | n/a | n/a | n/a | n/a |
Intellikine LLC
US Patent
| Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or... |
US Patent US9828378 (2017)
BindingDB Entry DOI: 10.7270/Q2542QWN |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha
(Homo sapiens (Human)) | BDBM315509
(US10172858, Table 2.5 | US10544104, Compound 27 | ...)Show SMILES COc1ccc2[nH]c(cc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C17H18N6O/c1-9(2)23-17-14(16(18)19-8-20-17)15(22-23)13-7-10-6-11(24-3)4-5-12(10)21-13/h4-9,21H,1-3H3,(H2,18,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >500 | n/a | n/a | n/a | n/a | n/a | n/a |
INTELLIKINE LLC
US Patent
| Assay Description
This assay is relatively simple, reasonably sensitive, and the peptide substrate can be adjusted both in terms of sequence and concentration to meet ... |
US Patent US10172858 (2019)
BindingDB Entry DOI: 10.7270/Q2736T01 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM315509
(US10172858, Table 2.5 | US10544104, Compound 27 | ...)Show SMILES COc1ccc2[nH]c(cc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C17H18N6O/c1-9(2)23-17-14(16(18)19-8-20-17)15(22-23)13-7-10-6-11(24-3)4-5-12(10)21-13/h4-9,21H,1-3H3,(H2,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >500 | n/a | n/a | n/a | n/a | n/a | n/a |
INTELLIKINE LLC
US Patent
| Assay Description
This assay is relatively simple, reasonably sensitive, and the peptide substrate can be adjusted both in terms of sequence and concentration to meet ... |
US Patent US10172858 (2019)
BindingDB Entry DOI: 10.7270/Q2736T01 |
More data for this
Ligand-Target Pair | |
Cytosolic arginine sensor for mTORC1 subunit 1
(Homo sapiens (Human)) | BDBM315509
(US10172858, Table 2.5 | US10544104, Compound 27 | ...)Show SMILES COc1ccc2[nH]c(cc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C17H18N6O/c1-9(2)23-17-14(16(18)19-8-20-17)15(22-23)13-7-10-6-11(24-3)4-5-12(10)21-13/h4-9,21H,1-3H3,(H2,18,19,20) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >500 | n/a | n/a | n/a | n/a | n/a | n/a |
Intellikine LLC
US Patent
| Assay Description
Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or... |
US Patent US9828378 (2017)
BindingDB Entry DOI: 10.7270/Q2542QWN |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1, putative
(Cryptosporidium parvum (strain Iowa II)) | BDBM315509
(US10172858, Table 2.5 | US10544104, Compound 27 | ...)Show SMILES COc1ccc2[nH]c(cc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C17H18N6O/c1-9(2)23-17-14(16(18)19-8-20-17)15(22-23)13-7-10-6-11(24-3)4-5-12(10)21-13/h4-9,21H,1-3H3,(H2,18,19,20) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 623 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this
Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM315509
(US10172858, Table 2.5 | US10544104, Compound 27 | ...)Show SMILES COc1ccc2[nH]c(cc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C17H18N6O/c1-9(2)23-17-14(16(18)19-8-20-17)15(22-23)13-7-10-6-11(24-3)4-5-12(10)21-13/h4-9,21H,1-3H3,(H2,18,19,20) | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 623 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II)) | BDBM315509
(US10172858, Table 2.5 | US10544104, Compound 27 | ...)Show SMILES COc1ccc2[nH]c(cc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C17H18N6O/c1-9(2)23-17-14(16(18)19-8-20-17)15(22-23)13-7-10-6-11(24-3)4-5-12(10)21-13/h4-9,21H,1-3H3,(H2,18,19,20) | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 623 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this
Ligand-Target Pair | |