Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 436.4 BDBM360515

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM360515 (N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)-5...) Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2noc(n2)-c2ccccc2)c2cnccc12 Show InChI InChI=1S/C26H20N4O3/c1-32-20-9-5-8-18(14-20)21-11-10-19(23-16-27-13-12-22(21)23)15-28-25(31)24-29-26(33-30-24)17-6-3-2-4-7-17/h2-14,16H,15H2,1H3,(H,28,31)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharpe & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9828369 (2017) BindingDB Entry DOI: 10.7270/Q2DN47C7
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