Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM50122253
(CHEMBL3617639)Show SMILES COc1cccc(c1)N1C[C@@H](C)n2nc(COc3ccc(Cl)cn3)cc2C1=O |r| Show InChI InChI=1S/C20H19ClN4O3/c1-13-11-24(16-4-3-5-17(9-16)27-2)20(26)18-8-15(23-25(13)18)12-28-19-7-6-14(21)10-22-19/h3-10,13H,11-12H2,1-2H3/t13-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 313 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay |
J Med Chem 58: 7485-500 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM50122253
(CHEMBL3617639)Show SMILES COc1cccc(c1)N1C[C@@H](C)n2nc(COc3ccc(Cl)cn3)cc2C1=O |r| Show InChI InChI=1S/C20H19ClN4O3/c1-13-11-24(16-4-3-5-17(9-16)27-2)20(26)18-8-15(23-25(13)18)12-28-19-7-6-14(21)10-22-19/h3-10,13H,11-12H2,1-2H3/t13-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay |
J Med Chem 58: 7485-500 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50122253
(CHEMBL3617639)Show SMILES COc1cccc(c1)N1C[C@@H](C)n2nc(COc3ccc(Cl)cn3)cc2C1=O |r| Show InChI InChI=1S/C20H19ClN4O3/c1-13-11-24(16-4-3-5-17(9-16)27-2)20(26)18-8-15(23-25(13)18)12-28-19-7-6-14(21)10-22-19/h3-10,13H,11-12H2,1-2H3/t13-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.13E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assay |
J Med Chem 58: 7485-500 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50122253
(CHEMBL3617639)Show SMILES COc1cccc(c1)N1C[C@@H](C)n2nc(COc3ccc(Cl)cn3)cc2C1=O |r| Show InChI InChI=1S/C20H19ClN4O3/c1-13-11-24(16-4-3-5-17(9-16)27-2)20(26)18-8-15(23-25(13)18)12-28-19-7-6-14(21)10-22-19/h3-10,13H,11-12H2,1-2H3/t13-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.07E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assay |
J Med Chem 58: 7485-500 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P |
More data for this
Ligand-Target Pair | |