Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Programmed cell death 1 ligand 1
(Homo sapiens (Human)) | BDBM482526
(US10919852, Compound TABLE 1.225 | US11708326, Com...)Show SMILES Cc1c(OCCCN2CCC(F)CC2)cccc1-c1cccc2[C@H](CCc12)Oc1cc(OCc2cc(cc(c2)C#N)C#N)c(CN[C@H]2CCC[C@H]2O)cc1Cl |r| Show InChI InChI=1S/C45H48ClFN4O4/c1-29-35(6-3-11-42(29)53-19-5-16-51-17-14-34(47)15-18-51)36-7-2-8-38-37(36)12-13-43(38)55-45-24-44(54-28-32-21-30(25-48)20-31(22-32)26-49)33(23-39(45)46)27-50-40-9-4-10-41(40)52/h2-3,6-8,11,20-24,34,40-41,43,50,52H,4-5,9-10,12-19,27-28H2,1H3/t40-,41+,43-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q22N56DJ |
More data for this
Ligand-Target Pair | |
Programmed cell death protein 1
(Homo sapiens) | BDBM482526
(US10919852, Compound TABLE 1.225 | US11708326, Com...)Show SMILES Cc1c(OCCCN2CCC(F)CC2)cccc1-c1cccc2[C@H](CCc12)Oc1cc(OCc2cc(cc(c2)C#N)C#N)c(CN[C@H]2CCC[C@H]2O)cc1Cl |r| Show InChI InChI=1S/C45H48ClFN4O4/c1-29-35(6-3-11-42(29)53-19-5-16-51-17-14-34(47)15-18-51)36-7-2-8-38-37(36)12-13-43(38)55-45-24-44(54-28-32-21-30(25-48)20-31(22-32)26-49)33(23-39(45)46)27-50-40-9-4-10-41(40)52/h2-3,6-8,11,20-24,34,40-41,43,50,52H,4-5,9-10,12-19,27-28H2,1H3/t40-,41+,43-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemoCentryx, Inc.
US Patent
| Assay Description
96 Well plates were coated with 1 g/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in PBS (W... |
US Patent US10919852 (2021)
BindingDB Entry DOI: 10.7270/Q2RF5Z3R |
More data for this
Ligand-Target Pair | |