Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mineralocorticoid receptor
(Homo sapiens (Human)) | BDBM50444189
(CHEMBL3093455)Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)NC(Cn1ccc2ncccc12)C(F)(F)F Show InChI InChI=1S/C19H20F3N3O2S/c1-12-9-13(2)18(14(3)10-12)28(26,27)24-17(19(20,21)22)11-25-8-6-15-16(25)5-4-7-23-15/h4-10,17,24H,11H2,1-3H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Binding affinity to mineralocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assay |
Bioorg Med Chem Lett 23: 6640-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50444189
(CHEMBL3093455)Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)NC(Cn1ccc2ncccc12)C(F)(F)F Show InChI InChI=1S/C19H20F3N3O2S/c1-12-9-13(2)18(14(3)10-12)28(26,27)24-17(19(20,21)22)11-25-8-6-15-16(25)5-4-7-23-15/h4-10,17,24H,11H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Displacement of TAMRA-labeled dexamethasone from glucocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assay |
Bioorg Med Chem Lett 23: 6640-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5 |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50444189
(CHEMBL3093455)Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)NC(Cn1ccc2ncccc12)C(F)(F)F Show InChI InChI=1S/C19H20F3N3O2S/c1-12-9-13(2)18(14(3)10-12)28(26,27)24-17(19(20,21)22)11-25-8-6-15-16(25)5-4-7-23-15/h4-10,17,24H,11H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 24 hrs |
Bioorg Med Chem Lett 23: 6640-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5 |
More data for this Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50444189
(CHEMBL3093455)Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)NC(Cn1ccc2ncccc12)C(F)(F)F Show InChI InChI=1S/C19H20F3N3O2S/c1-12-9-13(2)18(14(3)10-12)28(26,27)24-17(19(20,21)22)11-25-8-6-15-16(25)5-4-7-23-15/h4-10,17,24H,11H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Displacement of TAMRA-labeled mifepristone from progesterone receptor (unknown origin) by fluorescence polarization competitive binding assay |
Bioorg Med Chem Lett 23: 6640-4 (2013)
Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5 |
More data for this Ligand-Target Pair | |