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Target
Sequence
Name
&
Ki
IC50
Kd
EC50
Rate constants
ΔG°
ΔH°
-TΔS°
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IC50
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Compile Data Set for Download or QSAR
Marvin 2D Structure
The following exact ligands are found in BindingDB
Wt: 575.0
BDBM50584720
Purchase
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
20
hits in this display
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
High affinity nerve growth factor receptor
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
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B.MOAD
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MCE
PC cid
PC sid
UniChem
Article
PubMed
1
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to TrkA (unknown origin) assessed as inhibition constant by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
1
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to TrkB (unknown origin) assessed as inhibition constant by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
NT-3 growth factor receptor
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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MCE
PC cid
PC sid
UniChem
Article
PubMed
1
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to TrkC (unknown origin) assessed as inhibition constant by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
8
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to TrkA G595R mutant (unknown origin) assessed as inhibition constant by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
11
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to TrkA G667C mutant (unknown origin) assessed as inhibition constant by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
NT-3 growth factor receptor
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
2
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of TrkC (unknown origin) by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
2
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of TrkB (unknown origin) by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
2
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of wild type TrkA (unknown origin) using poly(Glu: Tyr) as substrate preincubated for 15 mins followed by substrate addition and further i...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
NT-3 growth factor receptor
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
2
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of wild type TrkC (unknown origin) using poly(Glu: Tyr) as substrate preincubated for 15 mins followed by substrate addition and further i...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of TrkA (unknown origin) by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of wild type TrkB (unknown origin) using poly(Glu: Tyr) as substrate preincubated for 15 mins followed by substrate addition and further i...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
12
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human Mer in presence of ATP by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
21
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of TrkA G595R mutant (unknown origin) by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
26
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of TrkA G667C mutant (unknown origin) by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase FRK
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
32
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human PTK5 in presence of ATP by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
Ephrin type-A receptor 8
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
101
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human EphA8 in presence of ATP by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
126
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human DDR1 in presence of ATP by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
Nuclear receptor subfamily 2 group C member 2
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
126
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human TAK1 in presence of ATP by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
138
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human RSE in presence of ATP by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fes/Fps
(Homo sapiens (Human))
BDBM50584720
(CHEMBL5088153)
Show SMILES
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Show InChI
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
269
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human FES in presence of ATP by radiometric assay
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01597
BindingDB Entry DOI:
10.7270/Q2377DMN
More data for this
Ligand-Target Pair