Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM50273040
((3,4-Dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)(4'-me...)Show SMILES Cc1ccc(cc1)-c1cccc(c1)C(=O)N1CCc2c(C1)[nH]c1ccccc21 Show InChI InChI=1S/C25H22N2O/c1-17-9-11-18(12-10-17)19-5-4-6-20(15-19)25(28)27-14-13-22-21-7-2-3-8-23(21)26-24(22)16-27/h2-12,15,26H,13-14,16H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leicester
Curated by ChEMBL
| Assay Description
Inhibition of human CDK4/GST-cyclin D1 expressed in Sf9 cells assessed as retinoblastoma GST-RB152 phosphorylation |
Bioorg Med Chem 16: 7728-39 (2008)
Article DOI: 10.1016/j.bmc.2008.07.002
BindingDB Entry DOI: 10.7270/Q2348K57 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50273040
((3,4-Dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)(4'-me...)Show SMILES Cc1ccc(cc1)-c1cccc(c1)C(=O)N1CCc2c(C1)[nH]c1ccccc21 Show InChI InChI=1S/C25H22N2O/c1-17-9-11-18(12-10-17)19-5-4-6-20(15-19)25(28)27-14-13-22-21-7-2-3-8-23(21)26-24(22)16-27/h2-12,15,26H,13-14,16H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.66E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leicester
Curated by ChEMBL
| Assay Description
Inhibition of human CDK2/GST-cyclin A expressed in Sf9 cells assessed as histone phosphorylation |
Bioorg Med Chem 16: 7728-39 (2008)
Article DOI: 10.1016/j.bmc.2008.07.002
BindingDB Entry DOI: 10.7270/Q2348K57 |
More data for this
Ligand-Target Pair | |