Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50417412
(CHEMBL1289047)Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2c(C)ccc3[nH]c(=O)ccc23)CC1 Show InChI InChI=1S/C26H28N4O/c1-18-6-10-24-21(9-11-26(31)28-24)20(18)12-13-29-14-16-30(17-15-29)25-5-3-4-23-22(25)8-7-19(2)27-23/h3-11H,12-17H2,1-2H3,(H,28,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human 5-HT1A receptor expressed in HEK293 cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7092-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.085 BindingDB Entry DOI: 10.7270/Q2MC919V |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50417412
(CHEMBL1289047)Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2c(C)ccc3[nH]c(=O)ccc23)CC1 Show InChI InChI=1S/C26H28N4O/c1-18-6-10-24-21(9-11-26(31)28-24)20(18)12-13-29-14-16-30(17-15-29)25-5-3-4-23-22(25)8-7-19(2)27-23/h3-11H,12-17H2,1-2H3,(H,28,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7092-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.085 BindingDB Entry DOI: 10.7270/Q2MC919V |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50417412
(CHEMBL1289047)Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2c(C)ccc3[nH]c(=O)ccc23)CC1 Show InChI InChI=1S/C26H28N4O/c1-18-6-10-24-21(9-11-26(31)28-24)20(18)12-13-29-14-16-30(17-15-29)25-5-3-4-23-22(25)8-7-19(2)27-23/h3-11H,12-17H2,1-2H3,(H,28,31) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Displacement of [3H]-citalopram in human SERT expressed in LLCPK cells by filtration assay |
Bioorg Med Chem Lett 20: 7092-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.085 BindingDB Entry DOI: 10.7270/Q2MC919V |
More data for this Ligand-Target Pair | |
Transcriptional regulator ERG
(Homo sapiens (Human)) | BDBM50417412
(CHEMBL1289047)Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2c(C)ccc3[nH]c(=O)ccc23)CC1 Show InChI InChI=1S/C26H28N4O/c1-18-6-10-24-21(9-11-26(31)28-24)20(18)12-13-29-14-16-30(17-15-29)25-5-3-4-23-22(25)8-7-19(2)27-23/h3-11H,12-17H2,1-2H3,(H,28,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Displacement of [3H]-dofetilide in human ERG expressed in CHO cells by proximity assay |
Bioorg Med Chem Lett 20: 7092-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.085 BindingDB Entry DOI: 10.7270/Q2MC919V |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1B
(Homo sapiens (Human)) | BDBM50417412
(CHEMBL1289047)Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2c(C)ccc3[nH]c(=O)ccc23)CC1 Show InChI InChI=1S/C26H28N4O/c1-18-6-10-24-21(9-11-26(31)28-24)20(18)12-13-29-14-16-30(17-15-29)25-5-3-4-23-22(25)8-7-19(2)27-23/h3-11H,12-17H2,1-2H3,(H,28,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 501 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay |
Bioorg Med Chem Lett 20: 7092-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.085 BindingDB Entry DOI: 10.7270/Q2MC919V |
More data for this Ligand-Target Pair | |