Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM223102
(N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-((1-(me...)Show SMILES Cc1nc(NC2CCN(C2)S(C)(=O)=O)cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)n1 Show InChI InChI=1S/C21H24ClN7O3S2/c1-12-5-4-6-15(22)19(12)28-20(30)16-10-23-21(33-16)27-18-9-17(24-13(2)25-18)26-14-7-8-29(11-14)34(3,31)32/h4-6,9-10,14H,7-8,11H2,1-3H3,(H,28,30)(H2,23,24,25,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.293 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
| Assay Description ABL activity assays were performed in 384-well plate using the FRET-based Z'-Lyteassay system and Tyr-2 peptide substrate according to the manufa... |
Chem Biol Drug Des 89: 420-427 (2017)
Article DOI: 10.1111/cbdd.12863 BindingDB Entry DOI: 10.7270/Q29C6W98 |
More data for this Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM223102
(N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-((1-(me...)Show SMILES Cc1nc(NC2CCN(C2)S(C)(=O)=O)cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)n1 Show InChI InChI=1S/C21H24ClN7O3S2/c1-12-5-4-6-15(22)19(12)28-20(30)16-10-23-21(33-16)27-18-9-17(24-13(2)25-18)26-14-7-8-29(11-14)34(3,31)32/h4-6,9-10,14H,7-8,11H2,1-3H3,(H,28,30)(H2,23,24,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 11.7 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
| Assay Description The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad... |
Chem Biol Drug Des 89: 420-427 (2017)
Article DOI: 10.1111/cbdd.12863 BindingDB Entry DOI: 10.7270/Q29C6W98 |
More data for this Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM223102
(N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-((1-(me...)Show SMILES Cc1nc(NC2CCN(C2)S(C)(=O)=O)cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)n1 Show InChI InChI=1S/C21H24ClN7O3S2/c1-12-5-4-6-15(22)19(12)28-20(30)16-10-23-21(33-16)27-18-9-17(24-13(2)25-18)26-14-7-8-29(11-14)34(3,31)32/h4-6,9-10,14H,7-8,11H2,1-3H3,(H,28,30)(H2,23,24,25,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 38.3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
| Assay Description The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad... |
Chem Biol Drug Des 89: 420-427 (2017)
Article DOI: 10.1111/cbdd.12863 BindingDB Entry DOI: 10.7270/Q29C6W98 |
More data for this Ligand-Target Pair | |