Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Caspase-3
(Homo sapiens (Human)) | BDBM10278
(3-Chloro-N-(1,2,3,4-tetrahydro-1,3,4-trioxoisoquin...)Show InChI InChI=1S/C12H9ClN2O4/c13-4-3-9(16)14-6-1-2-7-8(5-6)10(17)12(19)15-11(7)18/h1-2,5H,3-4H2,(H,14,16)(H,15,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institutes for Biological Sciences
| Assay Description The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I... |
J Med Chem 49: 1613-23 (2006)
Article DOI: 10.1021/jm050896o BindingDB Entry DOI: 10.7270/Q23N21MB |
More data for this Ligand-Target Pair | |
Caspase-7
(Homo sapiens (Human)) | BDBM10278
(3-Chloro-N-(1,2,3,4-tetrahydro-1,3,4-trioxoisoquin...)Show InChI InChI=1S/C12H9ClN2O4/c13-4-3-9(16)14-6-1-2-7-8(5-6)10(17)12(19)15-11(7)18/h1-2,5H,3-4H2,(H,14,16)(H,15,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institutes for Biological Sciences
| Assay Description The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I... |
J Med Chem 49: 1613-23 (2006)
Article DOI: 10.1021/jm050896o BindingDB Entry DOI: 10.7270/Q23N21MB |
More data for this Ligand-Target Pair | |
Caspase-6
(Homo sapiens (Human)) | BDBM10278
(3-Chloro-N-(1,2,3,4-tetrahydro-1,3,4-trioxoisoquin...)Show InChI InChI=1S/C12H9ClN2O4/c13-4-3-9(16)14-6-1-2-7-8(5-6)10(17)12(19)15-11(7)18/h1-2,5H,3-4H2,(H,14,16)(H,15,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 283 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institutes for Biological Sciences
| Assay Description The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I... |
J Med Chem 49: 1613-23 (2006)
Article DOI: 10.1021/jm050896o BindingDB Entry DOI: 10.7270/Q23N21MB |
More data for this Ligand-Target Pair | |
Caspase-2
(Homo sapiens (Human)) | BDBM10278
(3-Chloro-N-(1,2,3,4-tetrahydro-1,3,4-trioxoisoquin...)Show InChI InChI=1S/C12H9ClN2O4/c13-4-3-9(16)14-6-1-2-7-8(5-6)10(17)12(19)15-11(7)18/h1-2,5H,3-4H2,(H,14,16)(H,15,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institutes for Biological Sciences
| Assay Description The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I... |
J Med Chem 49: 1613-23 (2006)
Article DOI: 10.1021/jm050896o BindingDB Entry DOI: 10.7270/Q23N21MB |
More data for this Ligand-Target Pair | |
Caspase-8
(Homo sapiens (Human)) | BDBM10278
(3-Chloro-N-(1,2,3,4-tetrahydro-1,3,4-trioxoisoquin...)Show InChI InChI=1S/C12H9ClN2O4/c13-4-3-9(16)14-6-1-2-7-8(5-6)10(17)12(19)15-11(7)18/h1-2,5H,3-4H2,(H,14,16)(H,15,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 575 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institutes for Biological Sciences
| Assay Description The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I... |
J Med Chem 49: 1613-23 (2006)
Article DOI: 10.1021/jm050896o BindingDB Entry DOI: 10.7270/Q23N21MB |
More data for this Ligand-Target Pair | |