Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50085254
(1-[2-(4-Benzyl-2-chloro-phenoxy)-ethyl]-pyrrolidin...)Show InChI InChI=1S/C19H22ClNO/c20-18-15-17(14-16-6-2-1-3-7-16)8-9-19(18)22-13-12-21-10-4-5-11-21/h1-3,6-9,15H,4-5,10-14H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gyeongsang National University (GNU)
Curated by ChEMBL
| Assay Description Inhibition of human leukotriene A4 hydrolase |
Eur J Med Chem 46: 1593-603 (2011)
Article DOI: 10.1016/j.ejmech.2011.02.007 BindingDB Entry DOI: 10.7270/Q2K64JDG |
More data for this Ligand-Target Pair | |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50085254
(1-[2-(4-Benzyl-2-chloro-phenoxy)-ethyl]-pyrrolidin...)Show InChI InChI=1S/C19H22ClNO/c20-18-15-17(14-16-6-2-1-3-7-16)8-9-19(18)22-13-12-21-10-4-5-11-21/h1-3,6-9,15H,4-5,10-14H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Searle Research and Development
Curated by ChEMBL
| Assay Description Inhibitory activity was determined against Leukotriene A4 hydrolase |
J Med Chem 43: 721-35 (2000)
BindingDB Entry DOI: 10.7270/Q2CN74MZ |
More data for this Ligand-Target Pair | |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50085254
(1-[2-(4-Benzyl-2-chloro-phenoxy)-ethyl]-pyrrolidin...)Show InChI InChI=1S/C19H22ClNO/c20-18-15-17(14-16-6-2-1-3-7-16)8-9-19(18)22-13-12-21-10-4-5-11-21/h1-3,6-9,15H,4-5,10-14H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Searle Research and Development
Curated by ChEMBL
| Assay Description Inhibitory activity was determined for LTB4 production in human whole blood. |
J Med Chem 43: 721-35 (2000)
BindingDB Entry DOI: 10.7270/Q2CN74MZ |
More data for this Ligand-Target Pair | |