Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
(Homo sapiens (Human)) | BDBM201309
(US9187424, 146 | US9187424, 73)Show SMILES FC(F)(F)CCCOc1ccc(cc1)C1(CC(=C(C#N)C(=O)N1)c1ccc2ccccc2c1)C(F)(F)F |t:17| Show InChI InChI=1S/C27H20F6N2O2/c28-26(29,30)12-3-13-37-21-10-8-20(9-11-21)25(27(31,32)33)15-22(23(16-34)24(36)35-25)19-7-6-17-4-1-2-5-18(17)14-19/h1-2,4-11,14H,3,12-13,15H2,(H,35,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff... |
US Patent US9187424 (2015)
BindingDB Entry DOI: 10.7270/Q2FQ9VFG |
More data for this Ligand-Target Pair | |
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
(Homo sapiens (Human)) | BDBM201309
(US9187424, 146 | US9187424, 73)Show SMILES FC(F)(F)CCCOc1ccc(cc1)C1(CC(=C(C#N)C(=O)N1)c1ccc2ccccc2c1)C(F)(F)F |t:17| Show InChI InChI=1S/C27H20F6N2O2/c28-26(29,30)12-3-13-37-21-10-8-20(9-11-21)25(27(31,32)33)15-22(23(16-34)24(36)35-25)19-7-6-17-4-1-2-5-18(17)14-19/h1-2,4-11,14H,3,12-13,15H2,(H,35,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description The MGAT enzyme reactions were performed in CORNING Falcon 96-well Polypropylene plates, in a total volume of 60 uL of 50 mM Potassium Phosphate buff... |
US Patent US9187424 (2015)
BindingDB Entry DOI: 10.7270/Q2FQ9VFG |
More data for this Ligand-Target Pair | |
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
(Homo sapiens (Human)) | BDBM201309
(US9187424, 146 | US9187424, 73)Show SMILES FC(F)(F)CCCOc1ccc(cc1)C1(CC(=C(C#N)C(=O)N1)c1ccc2ccccc2c1)C(F)(F)F |t:17| Show InChI InChI=1S/C27H20F6N2O2/c28-26(29,30)12-3-13-37-21-10-8-20(9-11-21)25(27(31,32)33)15-22(23(16-34)24(36)35-25)19-7-6-17-4-1-2-5-18(17)14-19/h1-2,4-11,14H,3,12-13,15H2,(H,35,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 397 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Bristol-Myers Squibb Company
US Patent
| Assay Description MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy... |
US Patent US9187424 (2015)
BindingDB Entry DOI: 10.7270/Q2FQ9VFG |
More data for this Ligand-Target Pair | |
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
(Homo sapiens (Human)) | BDBM201309
(US9187424, 146 | US9187424, 73)Show SMILES FC(F)(F)CCCOc1ccc(cc1)C1(CC(=C(C#N)C(=O)N1)c1ccc2ccccc2c1)C(F)(F)F |t:17| Show InChI InChI=1S/C27H20F6N2O2/c28-26(29,30)12-3-13-37-21-10-8-20(9-11-21)25(27(31,32)33)15-22(23(16-34)24(36)35-25)19-7-6-17-4-1-2-5-18(17)14-19/h1-2,4-11,14H,3,12-13,15H2,(H,35,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 684 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Bristol-Myers Squibb Company
US Patent
| Assay Description MGAT2 enzyme was assayed using membranes isolated from Sf9 cells expressing the recombinant human MGAT2 cDNA with 2-monooleoylglycerol and [3H]-oleoy... |
US Patent US9187424 (2015)
BindingDB Entry DOI: 10.7270/Q2FQ9VFG |
More data for this Ligand-Target Pair | |