Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 380.3 BDBM50237261

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50237261 (CHEMBL4066115) Show SMILES FC(F)(F)c1ccc(cc1)-c1nc2ccccc2n(Cc2ccccc2)c1=O Show InChI InChI=1S/C22H15F3N2O/c23-22(24,25)17-12-10-16(11-13-17)20-21(28)27(14-15-6-2-1-3-7-15)19-9-5-4-8-18(19)26-20/h1-13H,14H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Activation of human CFTR expressed in FRT cells co-expressing YFP H148Q mutant assessed as increase in forskolin-stimulated iodide influx measured af...				J Med Chem 60: 2401-2410 (2017) Article DOI: 10.1021/acs.jmedchem.6b01759 BindingDB Entry DOI: 10.7270/Q2SN0C70
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