Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150473
(US10238633, Example 147 | US8987249, 147 | US97136...)Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2C(=O)NCc2c1 |r| Show InChI InChI=1S/C25H23FN4O2/c26-21-7-13(12-3-4-17-15(5-12)11-28-24(17)31)1-2-14(21)6-16(10-27)29-25(32)23-20-9-22(30-23)19-8-18(19)20/h1-5,7,16,18-20,22-23,30H,6,8-9,11H2,(H,28,31)(H,29,32)/t16-,18+,19-,20+,22-,23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation
| Assay Description The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in a 1:2 ratio with ... |
J Med Chem 50: 984-1000 (2007)
BindingDB Entry DOI: 10.7270/Q22R3TZF |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150473
(US10238633, Example 147 | US8987249, 147 | US97136...)Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2C(=O)NCc2c1 |r| Show InChI InChI=1S/C25H23FN4O2/c26-21-7-13(12-3-4-17-15(5-12)11-28-24(17)31)1-2-14(21)6-16(10-27)29-25(32)23-20-9-22(30-23)19-8-18(19)20/h1-5,7,16,18-20,22-23,30H,6,8-9,11H2,(H,28,31)(H,29,32)/t16-,18+,19-,20+,22-,23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | 6.0 | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod.... |
US Patent US9713606 (2017)
BindingDB Entry DOI: 10.7270/Q21G0P8M |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150473
(US10238633, Example 147 | US8987249, 147 | US97136...)Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2C(=O)NCc2c1 |r| Show InChI InChI=1S/C25H23FN4O2/c26-21-7-13(12-3-4-17-15(5-12)11-28-24(17)31)1-2-14(21)6-16(10-27)29-25(32)23-20-9-22(30-23)19-8-18(19)20/h1-5,7,16,18-20,22-23,30H,6,8-9,11H2,(H,28,31)(H,29,32)/t16-,18+,19-,20+,22-,23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 ug/ml, respectively), and then activated by mixing in a 1:2 ratio with a Cys... |
US Patent US8987249 (2015)
BindingDB Entry DOI: 10.7270/Q2KP80WG |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM150473
(US10238633, Example 147 | US8987249, 147 | US97136...)Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2C(=O)NCc2c1 |r| Show InChI InChI=1S/C25H23FN4O2/c26-21-7-13(12-3-4-17-15(5-12)11-28-24(17)31)1-2-14(21)6-16(10-27)29-25(32)23-20-9-22(30-23)19-8-18(19)20/h1-5,7,16,18-20,22-23,30H,6,8-9,11H2,(H,28,31)(H,29,32)/t16-,18+,19-,20+,22-,23-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation
| Assay Description To activate the proenzyme, 5 μl procathepsin K were mixed with 1 ul activation buffer, and incubated at room temperature for 30 min.5 μL te... |
J Med Chem 50: 984-1000 (2007)
BindingDB Entry DOI: 10.7270/Q22R3TZF |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM150473
(US10238633, Example 147 | US8987249, 147 | US97136...)Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc2C(=O)NCc2c1 |r| Show InChI InChI=1S/C25H23FN4O2/c26-21-7-13(12-3-4-17-15(5-12)11-28-24(17)31)1-2-14(21)6-16(10-27)29-25(32)23-20-9-22(30-23)19-8-18(19)20/h1-5,7,16,18-20,22-23,30H,6,8-9,11H2,(H,28,31)(H,29,32)/t16-,18+,19-,20+,22-,23-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | 3.5 | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr... |
US Patent US9713606 (2017)
BindingDB Entry DOI: 10.7270/Q21G0P8M |
More data for this Ligand-Target Pair | |