Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cytochrome P450 11B2, mitochondrial
(Homo sapiens (Human)) | BDBM25448
(4-[6-(4-fluorophenyl)-3,4-dihydronaphthalen-1-yl]p...)Show SMILES Fc1ccc(cc1)-c1ccc2C(=CCCc2c1)c1ccncc1 |c:12| Show InChI InChI=1S/C21H16FN/c22-19-7-4-15(5-8-19)17-6-9-21-18(14-17)2-1-3-20(21)16-10-12-23-13-11-16/h3-14H,1-2H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 121 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
| Assay Description The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro... |
J Med Chem 51: 5009-18 (2008)
Article DOI: 10.1021/jm800355c BindingDB Entry DOI: 10.7270/Q2TB156N |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM25448
(4-[6-(4-fluorophenyl)-3,4-dihydronaphthalen-1-yl]p...)Show SMILES Fc1ccc(cc1)-c1ccc2C(=CCCc2c1)c1ccncc1 |c:12| Show InChI InChI=1S/C21H16FN/c22-19-7-4-15(5-8-19)17-6-9-21-18(14-17)2-1-3-20(21)16-10-12-23-13-11-16/h3-14H,1-2H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
| Assay Description To measure CYP3A4 activity, the product of testosterone 6-hydroxylation, 6beta-hydroxytestosterone was determined. After incubation, the reaction was... |
J Med Chem 51: 5009-18 (2008)
Article DOI: 10.1021/jm800355c BindingDB Entry DOI: 10.7270/Q2TB156N |
More data for this Ligand-Target Pair | |
Steroid 17-alpha-hydroxylase/17,20 lyase
(Homo sapiens (Human)) | BDBM25448
(4-[6-(4-fluorophenyl)-3,4-dihydronaphthalen-1-yl]p...)Show SMILES Fc1ccc(cc1)-c1ccc2C(=CCCc2c1)c1ccncc1 |c:12| Show InChI InChI=1S/C21H16FN/c22-19-7-4-15(5-8-19)17-6-9-21-18(14-17)2-1-3-20(21)16-10-12-23-13-11-16/h3-14H,1-2H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Saarland University
| Assay Description The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr... |
J Med Chem 51: 5009-18 (2008)
Article DOI: 10.1021/jm800355c BindingDB Entry DOI: 10.7270/Q2TB156N |
More data for this Ligand-Target Pair | |
Cytochrome P450 11B1, mitochondrial
(Homo sapiens (Human)) | BDBM25448
(4-[6-(4-fluorophenyl)-3,4-dihydronaphthalen-1-yl]p...)Show SMILES Fc1ccc(cc1)-c1ccc2C(=CCCc2c1)c1ccncc1 |c:12| Show InChI InChI=1S/C21H16FN/c22-19-7-4-15(5-8-19)17-6-9-21-18(14-17)2-1-3-20(21)16-10-12-23-13-11-16/h3-14H,1-2H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
| Assay Description The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro... |
J Med Chem 51: 5009-18 (2008)
Article DOI: 10.1021/jm800355c BindingDB Entry DOI: 10.7270/Q2TB156N |
More data for this Ligand-Target Pair | |