Found 16 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prothrombin
(Bos taurus (Bovine)) | BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)Show SMILES NC(=N)c1cccc(C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28)/t24-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against thrombin |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Prothrombin
(Bos taurus (Bovine)) | BDBM50060015
(3-[3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(napht...)Show SMILES NC(=N)c1cccc(CC(NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against thrombin |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Anionic trypsin
(Bos taurus) | BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)Show SMILES NC(=N)c1cccc(C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28)/t24-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against trypsin |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Anionic trypsin
(Bos taurus) | BDBM50060015
(3-[3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(napht...)Show SMILES NC(=N)c1cccc(CC(NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against trypsin |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Prothrombin
(Bos taurus (Bovine)) | BDBM50060062
(3-[(S)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)Show SMILES NC(=N)c1cccc(C[C@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against thrombin |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)Show SMILES NC(=N)c1cccc(C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28)/t24-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against Plasmin. |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Bos taurus) | BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)Show SMILES NC(=N)c1cccc(C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28)/t24-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against coagulation factor X. |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Plasma kallikrein
(Homo sapiens (Human)) | BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)Show SMILES NC(=N)c1cccc(C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28)/t24-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against Kallikrein (PK) |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Bos taurus) | BDBM50060015
(3-[3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(napht...)Show SMILES NC(=N)c1cccc(CC(NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against coagulation factor X. |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Anionic trypsin
(Bos taurus) | BDBM50060062
(3-[(S)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)Show SMILES NC(=N)c1cccc(C[C@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against trypsin |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Vitamin K-dependent protein C
(Homo sapiens (Human)) | BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)Show SMILES NC(=N)c1cccc(C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28)/t24-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against Activated protein C |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50060015
(3-[3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(napht...)Show SMILES NC(=N)c1cccc(CC(NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against plasmin |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Urokinase-type plasminogen activator
(Homo sapiens (Human)) | BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)Show SMILES NC(=N)c1cccc(C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28)/t24-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against UK. |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)Show SMILES NC(=N)c1cccc(C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28)/t24-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against single-chain tissue-type plasminogen activator (sc-tissue plasminogen activator) |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Coagulation factor XII
(Homo sapiens (Human)) | BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)Show SMILES NC(=N)c1cccc(C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28)/t24-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against Coagulation factor XII |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |
Kallikrein-1
(Homo sapiens (Human)) | BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)Show SMILES NC(=N)c1cccc(C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)N2CCN(CCO)CC2)c1 Show InChI InChI=1S/C26H31N5O4S/c27-25(28)22-7-3-4-19(16-22)17-24(26(33)31-12-10-30(11-13-31)14-15-32)29-36(34,35)23-9-8-20-5-1-2-6-21(20)18-23/h1-9,16,18,24,29,32H,10-15,17H2,(H3,27,28)/t24-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Klinikum der Friedrich-Schiller-Universit£t Jena
Curated by ChEMBL
| Assay Description Inhibitory activity against glandular kallikrein (GK) |
J Med Chem 40: 3091-9 (1997)
Article DOI: 10.1021/jm960668h BindingDB Entry DOI: 10.7270/Q2Z60PRH |
More data for this Ligand-Target Pair | |