Found 10 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150570
(US10238633, Example 244 | US8987249, 244 | US97136...)Show SMILES NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19-,21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | 6.0 | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod.... |
US Patent US9713606 (2017)
BindingDB Entry DOI: 10.7270/Q21G0P8M |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150570
(US10238633, Example 244 | US8987249, 244 | US97136...)Show SMILES NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19-,21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation
| Assay Description
The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in a 1:2 ratio with ... |
J Med Chem 50: 984-1000 (2007)
BindingDB Entry DOI: 10.7270/Q22R3TZF |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150570
(US10238633, Example 244 | US8987249, 244 | US97136...)Show SMILES NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19-,21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 ug/ml, respectively), and then activated by mixing in a 1:2 ratio with a Cys... |
US Patent US8987249 (2015)
BindingDB Entry DOI: 10.7270/Q2KP80WG |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150379
(US10238633, Example 53 | US8987249, 53 | US9713606...)Show SMILES NC(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19?,21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | 6.0 | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod.... |
US Patent US9713606 (2017)
BindingDB Entry DOI: 10.7270/Q21G0P8M |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150379
(US10238633, Example 53 | US8987249, 53 | US9713606...)Show SMILES NC(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19?,21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation
| Assay Description
The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in a 1:2 ratio with ... |
J Med Chem 50: 984-1000 (2007)
BindingDB Entry DOI: 10.7270/Q22R3TZF |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150379
(US10238633, Example 53 | US8987249, 53 | US9713606...)Show SMILES NC(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19?,21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 ug/ml, respectively), and then activated by mixing in a 1:2 ratio with a Cys... |
US Patent US8987249 (2015)
BindingDB Entry DOI: 10.7270/Q2KP80WG |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM150570
(US10238633, Example 244 | US8987249, 244 | US97136...)Show SMILES NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation
| Assay Description
To activate the proenzyme, 5 μl procathepsin K were mixed with 1 ul activation buffer, and incubated at room temperature for 30 min.5 μL te... |
J Med Chem 50: 984-1000 (2007)
BindingDB Entry DOI: 10.7270/Q22R3TZF |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM150570
(US10238633, Example 244 | US8987249, 244 | US97136...)Show SMILES NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | 3.5 | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr... |
US Patent US9713606 (2017)
BindingDB Entry DOI: 10.7270/Q21G0P8M |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM150379
(US10238633, Example 53 | US8987249, 53 | US9713606...)Show SMILES NC(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19?,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | 3.5 | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr... |
US Patent US9713606 (2017)
BindingDB Entry DOI: 10.7270/Q21G0P8M |
More data for this
Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM150379
(US10238633, Example 53 | US8987249, 53 | US9713606...)Show SMILES NC(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| Show InChI InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19?,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation
| Assay Description
To activate the proenzyme, 5 μl procathepsin K were mixed with 1 ul activation buffer, and incubated at room temperature for 30 min.5 μL te... |
J Med Chem 50: 984-1000 (2007)
BindingDB Entry DOI: 10.7270/Q22R3TZF |
More data for this
Ligand-Target Pair | |