Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 485.9 BDBM300285

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neprilysin (Homo sapiens (Human))	BDBM300285 (US9593110, 21-2) Show SMILES NC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1coc(n1)C1CC1)C(O)=O Show InChI InChI=1S/C25H25ClFN3O4/c26-18-7-8-21(27)20(11-18)15-3-1-14(2-4-15)9-19(10-17(12-28)25(32)33)29-23(31)22-13-34-24(30-22)16-5-6-16/h1-4,7-8,11,13,16-17,19H,5-6,9-10,12,28H2,(H,29,31)(H,32,33)/t17-,19+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravence Biopharma R&D IP, LLC US Patent					Assay Description Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...				US Patent US9593110 (2017) BindingDB Entry DOI: 10.7270/Q2MC9224
					More data for this Ligand-Target Pair