Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM50129408
((R)-N-(4-Aminomethyl-phenyl)-2-((R)-3,3-difluoro-c...)Show SMILES NCc1ccc(NC(=O)[C@@](O)([C@@H]2CCC(F)(F)C2)c2ccccc2)cc1 Show InChI InChI=1S/C20H22F2N2O2/c21-19(22)11-10-16(12-19)20(26,15-4-2-1-3-5-15)18(25)24-17-8-6-14(13-23)7-9-17/h1-9,16,26H,10-13,23H2,(H,24,25)/t16-,20+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories
Curated by ChEMBL
| Assay Description Binding affinity against human muscarinic acetylcholine receptor M3 in transfected CHO cells |
Bioorg Med Chem Lett 13: 2167-72 (2003)
BindingDB Entry DOI: 10.7270/Q29G5M68 |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human)) | BDBM50129408
((R)-N-(4-Aminomethyl-phenyl)-2-((R)-3,3-difluoro-c...)Show SMILES NCc1ccc(NC(=O)[C@@](O)([C@@H]2CCC(F)(F)C2)c2ccccc2)cc1 Show InChI InChI=1S/C20H22F2N2O2/c21-19(22)11-10-16(12-19)20(26,15-4-2-1-3-5-15)18(25)24-17-8-6-14(13-23)7-9-17/h1-9,16,26H,10-13,23H2,(H,24,25)/t16-,20+/m1/s1 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories
Curated by ChEMBL
| Assay Description Binding affinity against human Muscarinic acetylcholine receptor M1 in transfected CHO cells |
Bioorg Med Chem Lett 13: 2167-72 (2003)
BindingDB Entry DOI: 10.7270/Q29G5M68 |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human)) | BDBM50129408
((R)-N-(4-Aminomethyl-phenyl)-2-((R)-3,3-difluoro-c...)Show SMILES NCc1ccc(NC(=O)[C@@](O)([C@@H]2CCC(F)(F)C2)c2ccccc2)cc1 Show InChI InChI=1S/C20H22F2N2O2/c21-19(22)11-10-16(12-19)20(26,15-4-2-1-3-5-15)18(25)24-17-8-6-14(13-23)7-9-17/h1-9,16,26H,10-13,23H2,(H,24,25)/t16-,20+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories
Curated by ChEMBL
| Assay Description Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells |
Bioorg Med Chem Lett 13: 2167-72 (2003)
BindingDB Entry DOI: 10.7270/Q29G5M68 |
More data for this Ligand-Target Pair | |