Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neuromedin-K receptor
(Homo sapiens (Human)) | BDBM50412949
(CHEMBL519790)Show SMILES Nc1c(nc2ccccc2c1C(=O)N[C@@H](C1CC1)c1cccc(F)c1)-c1cccc(F)c1 |r| Show InChI InChI=1S/C26H21F2N3O/c27-18-7-3-5-16(13-18)24(15-11-12-15)31-26(32)22-20-9-1-2-10-21(20)30-25(23(22)29)17-6-4-8-19(28)14-17/h1-10,13-15,24H,11-12,29H2,(H,31,32)/t24-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 6.31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neuroscience CEDD GlaxoSmithKline Research& Development
Curated by ChEMBL
| Assay Description Binding affinity to NK3 receptor |
Bioorg Med Chem Lett 19: 837-40 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.005 BindingDB Entry DOI: 10.7270/Q20K29S8 |
More data for this Ligand-Target Pair | |
Neuromedin-K receptor
(Homo sapiens (Human)) | BDBM50412949
(CHEMBL519790)Show SMILES Nc1c(nc2ccccc2c1C(=O)N[C@@H](C1CC1)c1cccc(F)c1)-c1cccc(F)c1 |r| Show InChI InChI=1S/C26H21F2N3O/c27-18-7-3-5-16(13-18)24(15-11-12-15)31-26(32)22-20-9-1-2-10-21(20)30-25(23(22)29)17-6-4-8-19(28)14-17/h1-10,13-15,24H,11-12,29H2,(H,31,32)/t24-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 6.31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern Ohio Universities Colleges of Medicine and Pharmacy
Curated by ChEMBL
| Assay Description Displacement of [125I]-MePhe7-NKB from human NK3 receptor expressed in CHO cells after 90 mins by gamma counting |
J Med Chem 53: 8080-8 (2010)
Article DOI: 10.1021/jm1010012 BindingDB Entry DOI: 10.7270/Q2736R5F |
More data for this Ligand-Target Pair | |