Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50050402
(6-(3-Chloro-phenylsulfanylmethyl)-pteridine-2,4-di...)Show InChI InChI=1S/C13H11ClN6S/c14-7-2-1-3-9(4-7)21-6-8-5-17-12-10(18-8)11(15)19-13(16)20-12/h1-5H,6H2,(H4,15,16,17,19,20) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Research Institute
Curated by ChEMBL
| Assay Description Inhibitory activity against Toxoplasma gondii dihydrofolate reductase |
J Med Chem 39: 1271-80 (1996)
Article DOI: 10.1021/jm950760y BindingDB Entry DOI: 10.7270/Q2154G39 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50050402
(6-(3-Chloro-phenylsulfanylmethyl)-pteridine-2,4-di...)Show InChI InChI=1S/C13H11ClN6S/c14-7-2-1-3-9(4-7)21-6-8-5-17-12-10(18-8)11(15)19-13(16)20-12/h1-5H,6H2,(H4,15,16,17,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Research Institute
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against rat liver dihydrofolate reductase |
J Med Chem 39: 1271-80 (1996)
Article DOI: 10.1021/jm950760y BindingDB Entry DOI: 10.7270/Q2154G39 |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50050402
(6-(3-Chloro-phenylsulfanylmethyl)-pteridine-2,4-di...)Show InChI InChI=1S/C13H11ClN6S/c14-7-2-1-3-9(4-7)21-6-8-5-17-12-10(18-8)11(15)19-13(16)20-12/h1-5H,6H2,(H4,15,16,17,19,20) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Research Institute
Curated by ChEMBL
| Assay Description Inhibitory activity against Pneumocystis carinii dihydrofolate reductase |
J Med Chem 39: 1271-80 (1996)
Article DOI: 10.1021/jm950760y BindingDB Entry DOI: 10.7270/Q2154G39 |
More data for this Ligand-Target Pair | |